CAPS Research
Permanent URI for this collectionhttps://hdl.handle.net/10735.1/7128
Browse
Browsing CAPS Research by Author "Song, Jane J."
Now showing 1 - 1 of 1
- Results Per Page
- Sort Options
Item RNA Control in Pain: Blame it on the Messenger(Blackwell Publishing Ltd, 2019-05-14) de la Peña, June Bryan I.; Song, Jane J.; Campbell, Zachary T.; de la Peña, June Bryan I.; Song, Jane J.; Campbell, Zachary T.mRNA function is meticulously controlled. We provide an overview of the integral role that posttranscriptional controls play in the perception of painful stimuli by sensory neurons. These specialized cells, termed nociceptors, precisely regulate mRNA polarity, translation, and stability. A growing body of evidence has revealed that targeted disruption of mRNAs and RNA-binding proteins robustly diminishes pain-associated behaviors. We propose that the use of multiple independent regulatory paradigms facilitates robust temporal and spatial precision of protein expression in response to a range of pain-promoting stimuli. ©2019 Wiley Periodicals, Inc.