Browsing by Author "Frizzo, C. P."
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Item Energetic and Topological Insights Into the Supramolecular Structure of Dicationic Ionic Liquids(Royal Soc Chemistry) Frizzo, C. P.; Bender, C. R.; Tier, A. Z.; Gindri, Izabelle M.; Salbego, P. R. S.; Meyer, A. R.; Martins, M. A. P.; Gindri, Izabelle M.The crystal structures of dicationic ILs [DBMIM][2BF(4)] (1) and [DBMIM][2Br]center dot[2H(2)O] (2) were investigated in order to explore the intermolecular interactions in these compounds. An energetic and topological approach for characterization of supramolecular clusters in organic crystals was used. The study of the crystals was done by considering the stabilization energy and topological properties such as contact surfaces and energy content between cations and neighboring anions (supramolecular clusters). The study showed that: 1 is auto-organized into layers (one-dimensional structure) by an anion-cation interaction (weak electrostatic and ionic), and the three-dimensional supramolecular structure of 2 is constructed through simultaneous interactions between cations, anions, and water molecules. This network results in interaction chains in two different directions. Additionally, the supramolecular cluster approach allowed evaluation of the participation of the topological component during the formation of the crystals of 1 and 2. Among the different types of interactions proposed, the most predominant was the one classified as type III, which has small and medium energy values, and a medium-sized contact surface. The thermal and morphological properties were also studied to further characterize these materials and to better understand the resulting structure-property relationships.Item Use of Dicationic Ionic Liquids as a Novel Liquid Platform for Dielectrophoretic Cell Manipulation(Royal Society of Chemistry) Taruvai Kalyana Kumar, Rajeshwari; De Mello Gindri, Izabelle.; Kinnamon, David; Rodrigues, Daniele C.; Frizzo, C. P.; Prasad, Shalini; 0000-0002-2404-3801 (Prasad, S); Taruvai Kalyana Kumar, Rajeshwari; De Mello Gindri, Izabelle; Kinnamon, David; Rodrigues, Daniele C.; Prasad, ShaliniSeparation, characterization and analysis of target cells demonstrate critical cues for diagnosis and monitoring of chronic diseases. Electrokinetic cell separation methods have been previously established to have greater efficiency when compared to traditional flow cytometry methods. Ionic liquids show promise in the design of conductive buffers with required electrical properties suitable for electrokinetic manipulation of cells with an enhanced signal to noise ratio (SNR). The goal of this project is to design and test tailored ionic liquid compositions with the hypothesis that dielectrophoretic forces are enhanced on cells while creating an environment for retaining cell integrity. We analysed two uniquely synthesized methylimidazolium based ionic liquids with a low toxicity as conductive suspension buffers for cell separation. These dicationic ionic liquids possess slight electrical and structural differences with high thermal stability. The two ionic liquids were tested for cytotoxicity and their ability to enhance SNR. We validated our hypothesis using osteosarcoma cells Saos-2 and MC3T3-E1 osteoblast cells. The tests were compared against commonly used dielectrophoretic sucrose-isotonic solution. The effects of electrical neutrality, charged particle effects, free charge screening due to ionic liquids from cells were studied using a single-shell model. Effects of ionic liquid and isotonic medium on electrokinetic signal from cells were studied through dielectrophoretic force profiles as a function of non-linear displacement of cells in the two ionic liquids and control media. We observed significant differences in electrokinetic responses between healthy and cancerous cells and steady increase in signal magnitude resulting in enhanced SNR using ILs when compared against sucrose buffer.