Browsing by Author "Li, G."
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Item ChIA-PET2: A Versatile and Flexible Pipeline for ChIA-PET Data Analysis(Oxford University Press, 2016-09-12) Li, G.; Chen, Y.; Snyder, M. P.; Zhang, Michael Q.; Zhang, Michael Q.ChIA-PET2 is a versatile and flexible pipeline for analyzing different types of ChIA-PET data from raw sequencing reads to chromatin loops. ChIA-PET2 integrates all steps required for ChIA-PET data analysis, including linker trimming, read alignment, duplicate removal, peak calling and chromatin loop calling. It supports different kinds of ChIA-PET data generated from different ChIA-PET protocols and also provides quality controls for different steps of ChIA-PET analysis. In addition, ChIA-PET2 can use phased genotype data to call allele-specific chromatin interactions. We applied ChIA-PET2 to different ChIA-PET datasets, demonstrating its significantly improved performance as well as its ability to easily process ChIA-PET raw data. ChIA-PET2 is available at https://github.com/GuipengLi/ChIA-PET2. © The Author(s) 2016.Item Impact of Power Structures in a Subcontracting Assembly System(Springer New York LLC) Li, G.; Li, L.; Liu, M.; Sethi, Suresh P.; Sethi, Suresh P.We investigate the impact of power structures on the production and pricing strategies in a decentralized subcontracting assembly system consisting of two suppliers (key supplier and subcontractor) and one manufacturer (assembler). The key supplier, who is also the general contractor, negotiates with the manufacturer and assigns partial component production to the subcontractor. We first identify a single power regime (SPR), in which either the key supplier or the manufacturer determines the wholesale price or the order/production quantity. Under SPR, we consider three power structures, namely, KSA, KAS, and SKA. We find that the assembly system will substantially benefit under KAS. Results show that the subcontracting mechanism between the two suppliers can increase each firm’s profit and disperse the bargaining power. Such a decentralization of powers can weaken the horizontal decentralization between the suppliers and improve the system’s performance, thereby achieving a win–win situation. Furthermore, we extend our analysis to a dual power regime (DPR), in which the key supplier or the manufacturer decides on price and quantity. We show that the proposed assembly system performs optimally under DPR. Moreover, the system will benefit if the firm that is substantially near the end market makes the centralization decision. Compared with the classical pull and push contract model, the proposed assembly system provides the best performance under DPR. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.Item Online Market Entry and Channel Sharing Strategy with Direct Selling Diseconomies in the Sharing Economy Era(Elsevier B.V., 2019-05-16) Li, G.; Zhang, X.; Chiu, S. -M; Liu, M.; Sethi, Suresh P.; Sethi, Suresh P.Channel sharing is an important marketing strategy for giant retailers who sell their own store brands and resell national brands for cooperative manufacturers simultaneously. To expand their market and increase profitability, national brand manufacturers may consider entering the online market through direct selling. To counter such threats, retailers may adopt a channel sharing strategy on whether to terminate the national brand product-reselling business. We analyze three scenarios, namely, the base scenario (the retailer sells both brands), the dual channel scenario (the manufacturer enters the online market while the retailer sells both brands), and the termination scenario (each firm sells their own brand because of the retailer's termination of the reselling business) to investigate the strategic interactions between the retailer and the manufacturer. We find that the termination of channel sharing by the retailer is an ineffective threat to prevent the manufacturer from entering the online market when the direct selling diseconomy is relatively low; otherwise, the effectiveness of the retailer's threat hinges on the store brand's quality. Specifically, the retailer's threat is valid if the store brand products' quality is low, whereas such threat is invalid if the store brand's quality is high. Interestingly, our results also reveal that the retailer's profit suffers “a cliff-like drop” in the store brand's quality level. This finding suggests that selling a higher quality store brand may hurt the retailer's profit once the store brand's quality exceeds a certain threshold. ©2019 Elsevier B.V.Item PDMS Based Coplanar Microfluidic Channels for the Surface Reduction of Oxidized GalinstanLi, G.; Parmar, M.; Kim, Daeyoung; Lee, Jeong-Bong; Lee, D. -WGalinstan has the potential to replace mercury-one of the most popular liquid metals. However, the easy oxidation of Galinstan restricts wide applicability of the material. In this paper, we report an effective reduction method for the oxidized Galinstan using gas permeable PDMS (polydimethlysiloxane)-based microfluidic channel. The complete study is divided into two parts-reduction of Galinstan oxide and behavior of reduced Galinstan oxide in a microfluidic channel. The reduction of Galinstan oxide is discussed on the basis of static as well as dynamic angles. The contact angle analyses help to find the extent of reduction by wetting characteristics of the oxide, to optimize PDMS thickness and to select suitable hydrochloric acid (HCl) concentration. The highest advancing angle of 155° and receding angle of 136° is achieved with 200 μm thick PDMS film and 37 wt% (weight percent) HCl solution. The behavior of reduced Galinstan oxide is analyzed in PDMS-based coplanar microfluidic channels fabricated using a simple micromolding technique. Galinstan in the microfluidic channel is surrounded by another coplanar channel filled with HCl solution. Due to the excellent permeability of PDMS, HCl permeates through the PDMS wall between the two channels (interchannel PDMS wall) and achieves a continuous chemical reaction with oxidized Galinstan. A Lab VIEW controlled syringe pump is used for observing the behavior of HCl treated Galinstan in the microfluidic channel. Further optimization of the microfluidic device has been conducted to minimize the reoxidation of reduced Galinstan oxide in the microfluidic channel.