Browsing by Author "Selvam, Anjan Panneer"
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Item An Electrochemical Sensor for the Detection of Antibiotic Contaminants in WaterJacobs, Michael; Nagaraj, V. J.; Mertz, T.; Selvam, Anjan Panneer; Ngo, T.; Prasad, ShaliniA nanochannel-based electrochemical sensor for the detection of trace amounts of erythromycin has been developed. The sensor is capable of specifically detecting erythromycin, at a sensitivity of 0.001 parts per trillion, in various water samples and has potential utility in the assessment of environmental water quality.Item Flexible Nanoporous Tunable Electrical Double Layer Biosensors for Sweat DiagnosticsMunje, Rujuta D.; Muthukumar, Sriram; Selvam, Anjan Panneer; Prasad, Shalini; 0000 0001 2765 4678 (Prasad, S); Munje, Rujuta D.; Selvam, Anjan Panneer; Prasad, ShaliniAn ultra-sensitive and highly specific electrical double layer (EDL) modulated biosensor, using nanoporous flexible substrates for wearable diagnostics is demonstrated with the detection of the stress biomarker cortisol in synthetic and human sweat. Zinc oxide thin film was used as active region in contact with the liquid i.e. synthetic and human sweat containing the biomolecules. Cortisol detection in sweat was accomplished by measuring and quantifying impedance changes due to modulation of the double layer capacitance within the electrical double layer through the application of a low orthogonally directed alternating current (AC) electric field. The EDL formed at the liquid-semiconductor interface was amplified in the presence of the nanoporous flexible substrate allowing for measuring the changes in the alternating current impedance signal due to the antibody-hormone interactions at diagnostically relevant concentrations. High sensitivity of detection of 1 pg/mL or 2.75 pmol cortisol in synthetic sweat and 1 ng/mL in human sweat is demonstrated with these novel biosensors. Specificity in synthetic sweat was demonstrated using a cytokine IL-1β. Cortisol detection in human sweat was demonstrated over a concentration range from 10–200 ng/mL.