Vanneste, Sven
Permanent URI for this collectionhttps://hdl.handle.net/10735.1/3653
Sven Vanneste is an Associate Professor of Auditory and Integrative Neuroscience. His research interests include:
- Neuroimaging
- Neurophysiology
- Invasive and non-invasive neuromodulation
- Bayesian predictive model of the brain
- Thalamocortical dysrhythmias
- Obsessive compulsive spectrum disorder
Learn more about Dr. Vanneste on his BBS People and Lab for Auditory and Integrative Neuroscience pages.
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Browsing Vanneste, Sven by Subject "Arrhythmia"
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Item Tinnitus and Neuropathic Pain Share a Common Neural Substrate in the Form of Specific Brain Connectivity and Microstate Profiles(Pergamon-Elsevier Science Ltd, 2018-08-22) Vanneste, Sven; To, Wing Ting; De Ridder, Dirk; 0000-0002-9906-1836 (Vanneste, S); Vanneste, Sven; To, Wing TingTinnitus and neuropathic pain share similar pathophysiological, clinical, and treatment characteristics. In this EEG study, a group of tinnitus (n = 100) and neuropathic pain (n = 100) patients are compared to each other and to a healthy control group (n = 100). Spectral analysis demonstrates gamma band activity within the primary auditory and somatosensory cortices in patients with tinnitus and neuropathic pain, respectively. A conjunction analysis further demonstrates an overlap of tinnitus and pain related activity in the anterior and posterior cingulate cortex as well as in the dorsolateral prefrontal cortex in comparison to healthy controls. Further analysis reveals that similar states characterize tinnitus and neuropathic pain patients, two of which differ from the healthy group and two of which are shared. Both pain and tinnitus patients spend half of the time in one specific microstate. Seed-based functional connectivity with the source within the predominant microstate shows delta, alpha1, and gamma lagged phase synchronization overlap with multiple brain areas between pain and tinnitus. These data suggest that auditory and somatosensory phantom perceptions share an overlapping brain network with common activation and connectivity patterns and are differentiated by specific sensory cortex gamma activation.Item Top-Down and Bottom-Up Regulated Auditory Phantom Perception(Soc Neuroscience, 2019-01-09) Vanneste, Sven; Alsalman, Ola; De Ridder, Dirk; 0000-0002-9906-1836 (Vanneste, S); Vanneste, Sven; Alsalman, OlaAuditory phantom percepts such as tinnitus are associated with auditory deafferentation. The idea is that auditory deafferentation limits the amount of information the brain can acquire to make sense of the world. Because of this, auditory deafferentation increases the uncertainty of the auditory environment. To minimize uncertainty, the deafferented brain will attempt to obtain or fill in the missing information. A proposed multiphase compensation model suggests two distinct types of bottom-up related tinnitus: an auditory cortex related tinnitus and a parahippocampal cortex related tinnitus. The weakness of this model is that it cannot explain why some people without hearing loss develop tinnitus, whereas conversely others with hearing loss do not develop tinnitus. In this human study, we provide evidence for a top-down type of tinnitus associated with a deficient noise-cancelling mechanism. A total of 72 participants (age: 40.96 ± 7.67 years; males: 48; females: 24) were recruited for this study. We demonstrate that top-down related tinnitus is related to a change in the pregenual anterior cingulate cortex that corresponds to increased activity in the auditory cortex. This is in accordance with the idea that tinnitus can have different generators as proposed in a recent model that suggests that different compensation mechanisms at a cortical level can be linked to phantom percepts.