Vanneste, Sven
Permanent URI for this collectionhttps://hdl.handle.net/10735.1/3653
Sven Vanneste is an Associate Professor of Auditory and Integrative Neuroscience. His research interests include:
- Neuroimaging
- Neurophysiology
- Invasive and non-invasive neuromodulation
- Bayesian predictive model of the brain
- Thalamocortical dysrhythmias
- Obsessive compulsive spectrum disorder
Learn more about Dr. Vanneste on his BBS People and Lab for Auditory and Integrative Neuroscience pages.
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Browsing Vanneste, Sven by Subject "Auditory cortex"
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Item Auditory Cortex tACS and tRNS for Tinnitus: Single Versus Multiple SessionsClaes, Laura; Stamberger, Hannah; de Heyning, Paul Van; De Ridder, Dirk; Vanneste, Sven; 0000-0002-9906-1836 (Vanneste, S); Lab for Clinical & Integrative NeuroscienceTinnitus is the perception of a sound in the absence of an external acoustic source, which often exerts a significant impact on the quality of life. Currently there is evidence that neuroplastic changes in both neural pathways are involved in the generation and maintaining of tinnitus. Neuromodulation has been suggested to interfere with these neuroplastic alterations. In this study we aimed to compare the effect of two upcoming forms of transcranial electrical neuromodulation: alternating current stimulation (tACS) and random noise stimulation (tRNS), both applied on the auditory cortex. A database with 228 patients with chronic tinnitus who underwent noninvasive neuromodulation was retrospectively analyzed. The results of this study show that a single session of tRNS induces a significant suppressive effect on tinnitus loudness and distress, in contrast to tACS. Multiple sessions of tRNS augment the suppressive effect on tinnitus loudness but have no effect on tinnitus distress. In conclusion this preliminary study shows a possibly beneficial effect of tRNS on tinnitus and can be a motivation for future randomized placebo-controlled clinical studies with auditory tRNS for tinnitus. Auditory alpha-modulated tACS does not seem to be contributing to the treatment of tinnitus.Item Pairing Sound with Vagus Nerve Stimulation Modulates Cortical Synchrony and Phase Coherence in Tinnitus: An Exploratory Retrospective Study(Nature Publishing Group) Vanneste, Sven; Martin, Jeffrey S.; Rennaker, Robert L.; Kilgard, Michael P.; 0000 0001 2879 2132 (Rennaker, RL); 0000 0001 3852 473X (Kilgard, MP); 0000-0002-9906-1836 (Vanneste, S); Vanneste, Sven; Martin, Jeffrey S.; Rennaker, Robert L.; Kilgard, Michael P.Recent research has shown that vagus nerve stimulation (VNS) paired with tones or with rehabilitative training can help patients to achieve reductions in tinnitus perception or to expedite motor rehabilitation after suffering an ischemic stroke. The rationale behind this treatment is that VNS paired with experience can drive neural plasticity in a controlled and therapeutic direction. Since previous studies observed that gamma activity in the auditory cortex is correlated with tinnitus loudness, we assessed resting-state source-localized EEG before and after one to three months of VNS-tone pairing in chronic tinnitus patients. VNS-tone pairing reduced gamma band activity in left auditory cortex. VNStone pairing also reduced the phase coherence between the auditory cortex and areas associated with tinnitus distress, including the cingulate cortex. These results support the hypothesis that VNS-tone pairing can direct therapeutic neural plasticity. Targeted plasticity therapy might also be adapted to treat other conditions characterized by hypersynchronous neural activity.Item Polarity Specific Suppression Effects of Transcranial Direct Current Stimulation for Tinnitus(Hindawi Pub. Corp) Joos, Kathleen; De Ridder, Dirk; Van, de Heyning; Vanneste, SvenTinnitus is the perception of a sound in the absence of an external auditory stimulus and affects 10-15% of the Western population. Previous studies have demonstrated the therapeutic effect of anodal transcranial direct current stimulation (tDCS) over the left auditory cortex on tinnitus loudness, but the effect of this presumed excitatory stimulation contradicts with the underlying pathophysiological model of tinnitus. Therefore, we included 175 patients with chronic tinnitus to study polarity specific effects of a single tDCS session over the auditory cortex (39 anodal, 136 cathodal). To assess the effect of treatment, we used the numeric rating scale for tinnitus loudness and annoyance. Statistical analysis demonstrated a significant main effect for tinnitus loudness and annoyance, but for tinnitus annoyance anodal stimulation has a significantly more pronounced effect than cathodal stimulation. We hypothesize that the suppressive effect of tDCS on tinnitus loudness may be attributed to a disrupting effect of ongoing neural hyperactivity, independent of the inhibitory or excitatory effects and that the reduction of annoyance may be induced by influencing adjacent or functionally connected brain areas involved in the tinnitus related distress network. Further research is required to explain why only anodal stimulation has a suppressive effect on tinnitus annoyance. ;Item Tinnitus Distress: A Paradoxical Attention to the Sound?(Springer-Verlag GmbH and Co., 2019-05-31) Kandeepan, S.; Maudoux, A.; Ribeiro de Paula, D.; Zheng, J. Y.; Cabay, J. E.; Gómez, F.; Chronik, B. A.; Ridder, D.; Vanneste, Sven; Soddu, A.; 0000-0002-9906-1836 (Vanneste, S); Vanneste, SvenTinnitus, the perception of sound in the absence of external stimuli, is often a disturbing symptom for which the underlying functional neuroanatomy still remains poorly understood. Most studies have focused solely on functional connectivity changes in the auditory cortex of tinnitus patients. The aim of this study was to investigate whether a correlation exists between tinnitus behavioural scores and functional brain connectivity of five resting-state networks comprising the auditory, the default mode, the external control left and right, and the salience network. For this purpose, a large sample of one hundred and thirty-five subjects underwent resting-state functional magnetic resonance imaging and their behavioural scores were obtained using clinical evaluations. Networks were extracted using independent component analysis, and functional connectivity patterns in the extracted networks were evaluated by a graph theoretical approach. The effects of tinnitus for each network were investigated by correlating the graph strength of all the regions with the tinnitus behavioural scores using stepwise fit regression analysis. Results indicated that alterations of functional interactions between key neural circuits of the brain are not limited to one single network. In particular, tinnitus distress showed a strong correlation with the connectivity pattern within and between the right executive control network and the other four resting-state networks, indicating that tinnitus distress is probably the consequence of a hyperactive attention condition. Among the behavioural scores, the strongest correlation was observed between age and hearing loss, while the tinnitus objective loudness was not correlated with any behavioural scores. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.Item Top-Down and Bottom-Up Regulated Auditory Phantom Perception(Soc Neuroscience, 2019-01-09) Vanneste, Sven; Alsalman, Ola; De Ridder, Dirk; 0000-0002-9906-1836 (Vanneste, S); Vanneste, Sven; Alsalman, OlaAuditory phantom percepts such as tinnitus are associated with auditory deafferentation. The idea is that auditory deafferentation limits the amount of information the brain can acquire to make sense of the world. Because of this, auditory deafferentation increases the uncertainty of the auditory environment. To minimize uncertainty, the deafferented brain will attempt to obtain or fill in the missing information. A proposed multiphase compensation model suggests two distinct types of bottom-up related tinnitus: an auditory cortex related tinnitus and a parahippocampal cortex related tinnitus. The weakness of this model is that it cannot explain why some people without hearing loss develop tinnitus, whereas conversely others with hearing loss do not develop tinnitus. In this human study, we provide evidence for a top-down type of tinnitus associated with a deficient noise-cancelling mechanism. A total of 72 participants (age: 40.96 ± 7.67 years; males: 48; females: 24) were recruited for this study. We demonstrate that top-down related tinnitus is related to a change in the pregenual anterior cingulate cortex that corresponds to increased activity in the auditory cortex. This is in accordance with the idea that tinnitus can have different generators as proposed in a recent model that suggests that different compensation mechanisms at a cortical level can be linked to phantom percepts.