Rodrigues, Danieli C.
Permanent URI for this collectionhttps://hdl.handle.net/10735.1/4062
Danieli Rodrigues is an Assistant Professor of Biomedical Engineering. Serving as a Research Engineer within the medical device industry, she developed test methods for performance verification and validation of new designs of hip and knee prostheses and related surgical instrumentation. Her graduate research focused on orthopedic biomaterials, primarily working on the characterization of corrosion and failure mechanisms of hip implants and development of acrylic two-solution bone cements for treatment of spinal compression fractures.
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Browsing Rodrigues, Danieli C. by Subject "Ceramics"
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Item Corrosion Behavior of Zirconia in Acidulated Phosphate Fluoride(Faculdade De Odontologia De Bauru) Thomas, Anie; Sridhar, Sathyanarayanan; Aghyarian, Shant; Watkins-Curry, P.; Chan, J. Y.; Pozzi, A.; Rodrigues, Danielli C.; Thomas, Anie; Sridhar, Sathyanarayanan; Aghyarian, Shant; Rodrigues, Danielli C.Objective: The corrosion behavior of zirconia in acidulated phosphate fluoride (APF) representing acidic environments and fluoride treatments was studied. Material and Methods: Zirconia rods were immersed in 1.23% and 0.123% APF solutions and maintained at 37°C for determined periods of time. Surfaces of all specimens were imaged using digital microscopy and scanning electron microscopy (SEM). Sample mass and dimensions were measured for mass loss determination. Samples were characterized by powder X-ray diffraction (XRD) to detect changes in crystallinity. A biosensor based on electrochemical impedance spectroscopy (EIS) was used to detect ion dissolution of material into the immersion media. Results: Digital microscopy revealed diminishing luster of the materials and SEM showed increased superficial corrosion of zirconia submerged in 1.23% APF. Although no structural change was found, the absorption of salts (sodium phosphate) onto the surface of the materials bathed in 0.123% APF was significant. EIS indicated a greater change of impedance for the immersion solutions with increasing bathing time. Conclusion: Immersion of zirconia in APF solutions showed deterioration limited to the surface, not extending to the bulk of the material. Inferences on zirconia performance in acidic oral environment can be elucidated from the study. ©2016, Journal of Applied Oral Science. All rights reserved.Item In Vitro Evaluation of Cell Compatibility of Dental Cements Used with Titanium Implant Components(Wiley, 2019-02) Marvin, Jason C.; Gallegos, Silvia I.; Parsaei, Shaida; Rodrigues, Danieli C.; 0000-0002-0389-0833 (Rodrigues, DC); Marvin, Jason C.; Gallegos, Silvia I.; Parsaei, Shaida; Rodrigues, Danieli C.Purpose To evaluate the biocompatibility of five dental cement compositions after directly exposing human gingival fibroblast (HGF) and MC3T3-E1 preosteoblast cells to cement alone and cement applied on commercially pure titanium (cpTi) specimens. Materials and Methods Nanostructurally integrated bioceramic (NIB), resin (R), resin-modified glass ionomer (RMGIC), zinc oxide eugenol (ZOE), and zinc phosphate (ZP) compositions were prepared according to the respective manufacturer's instructions. Samples were prepared in cylindrical Teflon molds or applied over the entire surface of polished cpTi discs. All samples were cured for 0.5, 1, 12, or 24 hours post-mixing. Direct contact testing was conducted according to ISO 10993 by seeding 6-well plates at 350,000 cells/well. Plates were incubated at 37 degrees C in a humidified atmosphere with 5% CO2 for 24 hours before individually plating samples and cpTi control discs. Plates were then incubated for an additional 24 hours. Microtetrazolium (MTT) cell viability assays were used to measure sample cytotoxicity. Results For samples that cured for 24 hours prior to direct contact exposure, only NIB and ZP cements when cemented on cpTi demonstrated cell viability percentages above the minimum biocompatibility requirement (>= 70%) for both the investigative cell lines. R, RMGIC, and ZOE cements exhibited moderate to severe cytotoxic effects on both cell lines in direct contact and when cemented on cpTi specimens. For HGF cells, ZOE cemented-cpTi specimens exhibited significantly decreased cytotoxicity, whereas RMGIC cemented-cpTi specimens exhibited significantly increased cytotoxicity. Conclusions Despite previous studies that showed enhanced cpTi corrosion activity for fluoride-containing compositions (NIB and ZP), there was no significant difference in cytotoxicity between cement alone and cemented-cpTi. In general, the MC3T3-E1 preosteoblast cells were more sensitive than HGF cells to cement composition. Ultimately, cement composition played a significant role in maintaining host cell compatibility. Results of this work help illustrate the impact of different cement formulations on host cell health and emphasize the need for understanding material properties when selecting certain formulations of dental cements, which can ultimately influence the survival of dental implant systems.