Lee, Jiyong

Permanent URI for this collectionhttps://hdl.handle.net/10735.1/6339

Jiyong Lee is an Assistant Professor of Chemistry and head of the Lee Lab. His research interests include:

  • Cancer stem cells
  • Tumor dormancy
  • Triple-negative breast cancer
  • Cancer metastasis and recurrence

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    A Phenotypic Cell-Binding Screen Identifies a Novel Compound Targeting Triple-Negative Breast Cancer
    Chen, Luxi; Long, Chao; Youn, Jonghae; Lee, Jiyong; 0000-0002-4455-3358 (Lee, J); Chen, Luxi; Long, Chao; Youn, Jonghae; Lee, Jiyong
    We describe a "phenotypic cell-binding screen" by which therapeutic candidate targeting cancer cells of a particular phenotype can be isolated without knowledge of drug targets. Chemical library beads are incubated with cancer cells of the phenotype of interest in the presence of cancer cells lacking the phenotype of interest, and then the beads bound to only cancer cells of the phenotype of interest are selected as hits. We have applied this screening strategy in discovering a novel compound (LC129-8) targeting triple-negative breast cancer (TNBC). LC129-8 displayed highly specific binding to TNBC in cancer cell lines and patient-derived tumor tissues. LC129-8 exerted anti-TNBC activity by inducing apoptosis, inhibiting proliferation, reversing epithelial-mesenchymal transition, downregulating cancer stem cell activity and blocking in vivo tumor growth.

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