School of Behavioral and Brain Sciences
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The mission of the School of Behavioral and Brain Sciences is to understand the intersection of mind, brain and behavior; enhance the health, education, and quality of life of children and families; and create and implement technologies and therapies that repair and strengthen human abilities. We accomplish these goals by recruiting and supporting outstanding faculty to conduct innovative research and student training in a climate that fosters collaboration across
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2019 Charles E. Williams II Advanced Leadership Institute Oratorical Contest Winning Speech
(2019-01-17)Patrick Nnoromele is a Eugene McDermott and National Merit Scholar. He is also a recipient of the Barry Goldwater Scholarship. He is majoring in Neuroscience and plans to attend medical school after graduation. This is the ... -
Gulf War Illness Associated with Abnormal Auditory P1 Event-Related Potential: Evidence of Impaired Cholinergic Processing Replicated in a National Sample
(Elsevier Ireland Ltd, 2018-11-10)Our team previously reported event-related potential (ERP) and hyperarousal patterns from a study of one construction battalion of the U.S. Naval Reserve who served during the 1991 Persian Gulf War. We sought to replicate ... -
Event-Related Neural Oscillation Changes Following Reasoning Training in Individuals with Mild Cognitive Impairment
(Elsevier Science B.V., 2018-10-17)Emerging evidence suggests cognitive training programs targeting higher-order reasoning may strengthen not only cognitive, but also neural functions in individuals with Mild Cognitive Impairment (MCI). However, research ... -
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain
(Soc Neuroscience, 2019-01-16)Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including ... -
Systemic Functional Adaptedness and Domain-General Cognition: Broadening the Scope of Evolutionary Psychology
(Springer, 2019-01-14)Evolutionary psychology tends to be associated with a massively modular cognitive architecture. On this framework of human cognition, an assembly of specialized information processors called modules developed under selection ... -
Gamma Oscillations During Episodic Memory Processing Provide Evidence for Functional Specialization in the Longitudinal Axis of the Human Hippocampus
(Wiley, 2018-11-05)The question of whether the anterior and posterior hippocampus serve different or complementary functional roles during episodic memory processing has been motivated by noteworthy findings in rodent experiments and from ... -
ASL-MRICloud: An Online Tool for the Processing of ASL MRI Data
(Wiley, 2018-12-26)Arterial spin labeling (ASL) MRI is increasingly used in research and clinical settings. The purpose of this work is to develop a cloud-based tool for ASL data processing, referred to as ASL-MRICloud, which may be useful ... -
Effects of Noise Exposure on Auditory Brainstem Response and Speech-in-Noise Tasks: A Review of the Literature
(Taylor & Francis Ltd, 2018-12-18)Objective: Short-term noise exposure that induces transient changes in thresholds has induced permanent cochlear synaptopathy in multiple species. Here, the literature was reviewed to gain translational insight into the ... -
The Time Course of Semantic and Relational Processing During Verbal Analogical Reasoning
(Academic Press Inc Elsevier Science, 2018-12-01)Analogy is an important ability that allows humans to discover relationships between information domains that often vary in surface and relational characteristics. Cognitive neuroscience studies of analogy have demonstrated ... -
Estimation of Brain Functional Connectivity from Hypercapnia BOLD MRI Data: Validation in a Lifespan Cohort of 170 Subjects
(Academic Press Inc Elsevier Science, 2018-11-16)Functional connectivity MRI, based on Blood-Oxygenation-Level-Dependent (BOLD) signals, is typically performed while the subject is at rest. On the other hand, BOLD is also widely used in physiological imaging such as ... -
Frontostriatal White Matter Connectivity: Age Differences and Associations with Cognition and BOLD Modulation
(Elsevier Inc., 2020-06-07)Despite the importance of cortico-striatal circuits to cognition, investigation of age effects on the structural circuitry connecting these regions is limited. The current study examined age effects on frontostriatal white ... -
Genetic Predisposition for Inflammation Exacerbates Effects of Striatal Iron Content on Cognitive Switching Ability in Healthy Aging
(Academic Press Inc Elsevier Science, 2018-10-25)Non-heme iron homeostasis interacts with inflammation bidirectionally, and both contribute to age-related decline in brain structure and function via oxidative stress. Thus, individuals with genetic predisposition for ... -
Sensorimotor Network Segregation Declines with Age and is Linked to GABA and to Sensorimotor Performance
(Academic Press Inc Elsevier Science, 2018-11-09)Aging is typically associated with declines in sensorimotor performance. Previous studies have linked some age-related behavioral declines to reductions in network segregation. For example, compared to young adults, older ... -
Emerging Neurotechnology for Antinoceptive Mechanisms and Therapeutics Discovery
(Elsevier Advanced Technology, 2018-11-13)The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to ... -
Hearing Healthcare in Remote or Resource-Constrained Environments
(Cambridge Univ Press, 2018-07-19)Background Hearing loss is a leading contributor to the global burden of disease, with more than 80 per cent of affected persons residing in low- and middle-income countries, typically where hearing health services are ... -
Vagus Nerve Stimulation as a Tool for Enhancing Extinction in Exposure-Based Therapies
(Springer, 2019-01)Rationale Emotionally traumatic experiences can lead to maladaptive memories that are enduring and intrusive. The goal of exposure-based therapies is to extinguish conditioned fears through repeated, unreinforced exposures ... -
The Relationship Between Age, Neural Differentiation, and Memory Performance
(Society for Neuroscience, 2018-11-02)Healthy aging is associated with decreased neural selectivity (dedifferentiation) in category-selective cortical regions. This finding has prompted the suggestion that dedifferentiation contributes to age-related cognitive ... -
The Antidiabetic Drug Metformin Prevents and Reverses Neuropathic Pain and Spinal Cord Microglial Activation in Male but not Female Mice
(Academic Press Ltd- Elsevier Science Ltd, 2018-11-01)Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK ... -
Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and its Putative Receptors GPR18 and GPR55
(Frontiers Media SA, 2019-01-08)Background: Marijuana extracts (cannabinoids) have been used for several millennia for pain treatment. Regarding the site of action, cannabinoids are highly promiscuous molecules, but only two cannabinoid receptors (CB₁ ... -
Tinnitus and Neuropathic Pain Share a Common Neural Substrate in the Form of Specific Brain Connectivity and Microstate Profiles
(Pergamon-Elsevier Science Ltd, 2018-08-22)Tinnitus and neuropathic pain share similar pathophysiological, clinical, and treatment characteristics. In this EEG study, a group of tinnitus (n = 100) and neuropathic pain (n = 100) patients are compared to each other ...
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