School of Behavioral and Brain Sciences
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The mission of the School of Behavioral and Brain Sciences is to understand the intersection of mind, brain and behavior; enhance the health, education, and quality of life of children and families; and create and implement technologies and therapies that repair and strengthen human abilities. We accomplish these goals by recruiting and supporting outstanding faculty to conduct innovative research and student training in a climate that fosters collaboration across
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Thalamocortical Dysrhythmia Detected by Machine Learning
Thalamocortical dysrhythmia (TCD) is a model proposed to explain divergent neurological disorders. It is characterized by a common oscillatory pattern in which resting-state alpha activity is replaced by cross-frequency ... -
Increased Parietal Circuit-Breaker Activity in Delta Frequency Band and Abnormal Delta/Theta Band Connectivity in Salience Network in Hyperacusis Subjects
Recent studies have suggested that hyperacusis, an abnormal hypersensitivity to ordinary environmental sounds, may be characterized by certain resting-state cortical oscillatory patterns, even with no sound stimulus. ... -
Changing Brain Networks Through Non-Invasive Neuromodulation
Background/Objective: Non-invasive neuromodulation techniques, such as repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), have increasingly been investigated for their ... -
Social Cognition Psychometric Evaluation: Results of the Final Validation Study
Social cognition is increasingly recognized as an important treatment target in schizophrenia; however, the dearth of well- validated measures that are suitable for use in clinical trials remains a significant limitation. ... -
Increased Social Cognitive Bias in Subclinical Paranoia
Background: Recent analyses from the SCOPE study have revealed significant relationships between measures of social cognitive biases and specific symptoms, such as paranoia, in individuals with schizophrenia (Buck et al, ... -
Brief Report: Adults with Autism Are Less Accurate at Predicting How Their Personality Traits Are Evaluated by Unfamiliar Observers
Social cognitive impairments in autism spectrum disorder (ASD) are well-documented, yet little research has examined whether ASD is also characterized by difficulties in meta-perception, or the ability to gauge how one is ... -
Pairing Sound with Vagus Nerve Stimulation Modulates Cortical Synchrony and Phase Coherence in Tinnitus: An Exploratory Retrospective Study
Recent research has shown that vagus nerve stimulation (VNS) paired with tones or with rehabilitative training can help patients to achieve reductions in tinnitus perception or to expedite motor rehabilitation after suffering ... -
17-β-Estradiol Induces Spreading Depression and Pain Behavior in Alert Female Rats
Aims: Test the putative contribution of 17-β-estradiol in the development of spreading depression (SD) events and head pain in awake, non-restrained rats. Main Methods: Female, Sprague-Dawley rats were intact or underwent ... -
A Critical Role for Dopamine D5 Receptors in Pain Chronicity in Male Mice
Dopaminergic modulation of spinal cord plasticity has long been recognized, but circuits affected by this system and the precise receptor subtypes involved in this modulation have not been defined. Dopaminergic modulation ... -
eIF4E Phosphorylation Influences BDNF mRNA Translation in Mouse Dorsal Root Ganglion Neurons
Plasticity in dorsal root ganglion (DRG) neurons that promotes pain requires activity-dependent mRNA translation. Protein synthesis inhibitors block the ability of many pain-promoting molecules to enhance excitability in ... -
The Neural Correlates of the Unified Percept of Alcohol-Related Craving: A fMRI and EEG Study
Alcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in ... -
Bi-Modal Stimulation in the Treatment of Tinnitus: A Study Protocol for an Exploratory Trial to Optimise Stimulation Parameters and Patient Subtyping
INTRODUCTION: Tinnitus is the perception of sound in the absence of a corresponding external acoustic stimulus. Bimodal neuromodulation is emerging as a promising treatment for this condition. The main objectives of this ... -
Higher-Order Cognitive Training Effects on Processing Speed-Related Neural Activity: A Randomized Trial
Higher-order cognitive training has shown to enhance performance in older adults, but the neural mechanisms underlying performance enhancement have yet to be fully disambiguated. This randomized trial examined changes in ... -
Mapping the Operational Landscape of MicroRNAs in Synthetic Gene Circuits.
(Nature Partner Journals, 2018-10-22)MicroRNAs are a class of short, noncoding RNAs that are ubiquitous modulators of gene expression, with roles in development, homeostasis, and disease. Engineered microRNAs are now frequently used as regulatory modules in ... -
Voice Gender and the Segregation of Competing Talkers: Perceptual Learning in Cochlear Implant Simulations
Two experiments explored the role of differences in voice gender in the recognition of speech masked by a competing talker in cochlear implant simulations. Experiment 1 confirmed that listeners with normal hearing receive ... -
Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest
Cross-frequency coupling (CFC) between slow and fast brain rhythms, in the form of phase-amplitude coupling (PAC), is proposed to enable the coordination of neural oscillatory activity required for cognitive processing. ... -
A Quantitative Electroencephalography Study on Cochlear Implant-Induced Cortical Changes in Single-Sided Deafness with Tinnitus
The mechanism of tinnitus suppression after cochlear implantation (CI) in single-sided deafness (SSD) is not fully understood. In this regard, by comparing pre-and post-CI quantitative electroencephalography (qEEG), we ... -
Using the Single Prolonged Stress Model to Examine the Pathophysiology of PTSD
The endurance of memories of emotionally arousing events serves the adaptive role of minimizing future exposure to danger and reinforcing rewarding behaviors. However, following a traumatic event, a subset of individuals ... -
Antioxidant Treatment with N-acetyl Cysteine Prevents the Development of Cognitive and Social Behavioral Deficits That Result from Perinatal Ketamine Treatment
Alterations of the normal redox state can be found in all stages of schizophrenia, suggesting a key role for oxidative stress in the etiology and maintenance of the disease. Pharmacological blockade of N-methyl-D-aspartic ... -
The Role of Nonverbal Working Memory in Morphosyntactic Processing by Children with Specific Language Impairment and Autism Spectrum Disorders
(BioMed Central, 2018-09-24)Background: Both children with autism spectrum disorders (ASD) and children with specific language impairment (SLI) have been shown to have difficulties with grammatical processing. A comparison of these two populations ...
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