Now showing items 1-3 of 3

    • Activity-Dependent FUS Dysregulation Disrupts Synaptic Homeostasis 

      Sephton, Chantelle F.; Tang, Amy A.; Kulkarni, Ashwinikumar; West, James; Brooks, Mieu; Stubblefield, Jeremy J.; Liu, Yun; Zhang, Michael Q.; Green, Carla B.; Huber, Kimberly M.; Huang, Eric J.; Herz, Joachim; Yu, Gang (Natl Acad Sciences, 2014-10-16)
      The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two neurodegenerative disorders that share similar clinical and ...
    • A Highly Efficient and Effective Motif Discovery Method for ChIP-Seq/ChIP-Chip Data using Positional Information 

      Ma, Xiaotu; Kulkarni, Ashwinikumar; Zhang, Zhihua; Xuan, Zhenyu; Serfling, Robert J. (Robert Joseph); Zhang, Michael Q. (2012-01-06)
      Identification of DNA motifs from ChIP-seq/ChIP-chip [chromatin immunoprecipitation (ChIP)] data is a powerful method for understanding the transcriptional regulatory network. However, most established methods are designed ...
    • New Fusion Transcripts Identified in Normal Karyotype Acute Myeloid Leukemia 

      Wen, H.; Li, Yongjin; Malek, S. N.; Kim, Y. C.; Xu, J.; Chen, P.; Xiao, F.; Huang, X.; Xuan, Zhenyu; Mankala, Shiva; Zhang, Michael Q. (2012-12-12)
      Genetic aberrations contribute to acute myeloid leukemia (AML). However, half of AML cases do not contain the well-known aberrations detectable mostly by cytogenetic analysis, and these cases are classified as normal ...