Now showing items 1-3 of 3

    • Histone Deacetylases Positively Regulate Transcription Through the Elongation Machinery 

      Greer, Celeste B.; Tanaka, Yoshiaki; Kim, Yoon Jung; Xie, Peng; Zhang, Michael Q.; Park, In-Hyun; Kim, Tae Hoon (Elsevier B.V., 2015-11-17)
      Transcription elongation regulates the expression of many genes, including oncogenes. Histone deacetylase (HDAC) inhibitors (HDACIs) block elongation, suggesting that HDACs are involved in gene activation. To understand ...
    • Hsa-miR-1246, Hsa-miR-320a and Hsa-miR-196b-5p Inhibitors can Reduce the Cytotoxicity of Ebola Virus Glycoprotein in Vitro 

      Sheng, MiaoMiao; Ying, Zhong; Yang,Chen; Du, JianChao; Ju, XiangWu; Chen, Zhao; GuiGen, Zhang; LiFang,Zhang; Liu, KangTai; Yang, Ning; Xie, Peng; Li, DangSheng; Zhang, Michael Q.; Jiang, ChengYu; ATLAS Collaboration (Science Press, 2014-09-12)
      Ebola virus (EBOV) causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91% in Zaire, the most lethal strain. Though the viral envelope glycoprotein (GP) mediates ...
    • Miror: A Method for Cell-Type Specific MicroRNA Occupancy Rate Prediction 

      Xie, Peng; Liu, Yu; Li, Yanda; Zhang, Michael Q.; Wang, Xiaowo (Royal Soc Chemistry, 2014-03-13)
      MicroRNA (miRNA) regulation is highly cell-type specific. It is sensitive to both the miRNA-mRNA relative abundance and the competitive endogenous RNA (ceRNA) effect. However, almost all existing miRNA target prediction ...