Dr. Steven Levene is a Professor of Bioengineering in the Department of Biological Sciences. He is also an affiliated faculty member in UTD's graduate programs in Bioinformatics and Computational Biology, and in Biotechnology. Professor Levene's research interests "involve protein-DNA interactions in site-specific recombination and the structure and dynamics of nucleic acids in solution."

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Recent Submissions

  • Free-Energy Calculations for Semi-Flexible Macromolecules: Applications to DNA Knotting and Looping 

    Giovan, Stefan M.; Scharein, Robert G.; Hanke, Andreas; Levene, Stephen D. (American Institute of Physics, 2014-11-07)
    We present a method to obtain numerically accurate values of configurational free energies of semiflexible macromolecular systems, based on the technique of thermodynamic integration combined with normal-mode analysis of ...
  • Measurements of DNA-Loop Formation via Cre-Mediated Recombination 

    Shoura, Massa J.; Vetcher, Alexandre; Giovan, Stefan; Levene, Stephen D.; Bardai, Farah; Bharadwaj, Anusha; Kesinger, Matthew R. (2012-05-15)
    The Cre recombination system has become an important tool for genetic manipulation of higher organisms and a model for site-specific DNA-recombination mechanisms employed by the λ-Int superfamily of recombinases. We report ...
  • Engineering Multiple Site-Specific Modifications in Supercoiled DNAs 

    Bharadwaj, Anusha; Kesinger, Matthew R.; Shoura, Massa J.; Vetcher, Alexandre; Levene, Stephen D. (2012-06-19)
    New techniques are needed in order to study the effects of DNA supercoiling on loop-mediated regulation. The thermodynamics of DNA looping depend periodically on the helical phasing between recognition sites. A long-term ...
  • DNA Looping in Topologically Constrained Domains 

    Bharadwaj, Anusha; Kesinger, Matthew R.; Shoura, Massa J.; Vetcher, Alexandre; Levene, Stephen D. (Oxford University Press., 2012-05-15)
    New techniques are needed in order to study the effects of DNA supercoiling on loop-mediated regulation. The thermodynamics of DNA looping depend periodically on the helical phasing between recognition sites. A long-term ...