• Event-Related Neural Oscillation Changes Following Reasoning Training in Individuals with Mild Cognitive Impairment 

  Mudar, Raksha A.; Nguyen, Lydia T.; Eroh, Justin; Chiang, Hsueh-Sheng; Rackley, Audette; Chapman, Sandra B. (Elsevier Science B.V., 2018-10-17)

  Emerging evidence suggests cognitive training programs targeting higher-order reasoning may strengthen not only cognitive, but also neural functions in individuals with Mild Cognitive Impairment (MCI). However, research ...

• Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain 

  Megat, Salim; Ray, Pradipta R.; Moy, Jamie K.; Lou, Tzu-Fang; Barragan-Iglesias, Paulino; Li, Yan; Pradhan, Grishma; Wanghzou, Andi; Ahmad, Ayesha; Burton, Michael D.; North, Robert Y.; Dougherty, Patrick M.; Khoutorsky, Arkady; Sonenberg, Nahum; Webster, Nevin R.; Dussor, Gregory; Campbell, Zachary T.; Price, Theodore J. (Soc Neuroscience, 2019-01-16)

  Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including ...

• Gamma Oscillations During Episodic Memory Processing Provide Evidence for Functional Specialization in the Longitudinal Axis of the Human Hippocampus 

  Lin, Jui-Jui; Umbach, Gray; Rugg, Michael D.; Lega, Bradley (Wiley, 2018-11-05)

  The question of whether the anterior and posterior hippocampus serve different or complementary functional roles during episodic memory processing has been motivated by noteworthy findings in rodent experiments and from ...

• ASL-MRICloud: An Online Tool for the Processing of ASL MRI Data 

  Li, Yang; Liu, Peiying; Li, Yue; Fan, Hongli; Su, Pan; Peng, Shin-Lei; Park, Denise C.; Rodrigue, Karen M.; Jiang, Hangyi; Faria, Andreia V.; Ceritoglu, Can; Miller, Michael; Mori, Susumu; Lu, Hanzhang (Wiley, 2018-12-26)

  Arterial spin labeling (ASL) MRI is increasingly used in research and clinical settings. The purpose of this work is to develop a cloud-based tool for ASL data processing, referred to as ASL-MRICloud, which may be useful ...

• Effects of Noise Exposure on Auditory Brainstem Response and Speech-in-Noise Tasks: A Review of the Literature 

  Le Prell, Colleen G. (Taylor & Francis Ltd, 2018-12-18)

  Objective: Short-term noise exposure that induces transient changes in thresholds has induced permanent cochlear synaptopathy in multiple species. Here, the literature was reviewed to gain translational insight into the ...

• Estimation of Brain Functional Connectivity from Hypercapnia BOLD MRI Data: Validation in a Lifespan Cohort of 170 Subjects 

  Hou, Xirui; Liu, Peiying; Gu, Hong; Chan, Micaela; Li, Yang; Peng, Shin-Lei; Wig, Gagan; Yang, Yihong; Park, Denise C.; Lu, Hanzhang (Academic Press Inc Elsevier Science, 2018-11-16)

  Functional connectivity MRI, based on Blood-Oxygenation-Level-Dependent (BOLD) signals, is typically performed while the subject is at rest. On the other hand, BOLD is also widely used in physiological imaging such as ...

• Frontostriatal White Matter Connectivity: Age Differences and Associations with Cognition and BOLD Modulation 

  Webb Christina E.; Hoagey, David A.; Rodrigue, Karen M.; Kennedy, Kristen M. (Elsevier Inc., 2020-06-07)

  Despite the importance of cortico-striatal circuits to cognition, investigation of age effects on the structural circuitry connecting these regions is limited. The current study examined age effects on frontostriatal white ...

• Genetic Predisposition for Inflammation Exacerbates Effects of Striatal Iron Content on Cognitive Switching Ability in Healthy Aging 

  Daugherty, Ana M.; Hoagey, David A.; Kennedy, Kristen M.; Rodrigue, Karen M. (Academic Press Inc Elsevier Science, 2018-10-25)

  Non-heme iron homeostasis interacts with inflammation bidirectionally, and both contribute to age-related decline in brain structure and function via oxidative stress. Thus, individuals with genetic predisposition for ...

• Sensorimotor Network Segregation Declines with Age and is Linked to GABA and to Sensorimotor Performance 

  Cassady, Kaitlin; Gagnon, Holly; Lalwani, Poortata; Simmonite, Molly; Foerster, Bradley; Park, Denise C.; Peltier, Scott J.; Petrou, Myria; Taylor, Stephan F.; Weissman, Daniel H.; Seidler, Rachael D.; Polk, Thad A. (Academic Press Inc Elsevier Science, 2018-11-09)

  Aging is typically associated with declines in sensorimotor performance. Previous studies have linked some age-related behavioral declines to reductions in network segregation. For example, compared to young adults, older ...

• Emerging Neurotechnology for Antinoceptive Mechanisms and Therapeutics Discovery 

  Black, Bryan J.; Atmaramani, Rahul; Plagens, Sarah; Campbell, Zachary T.; Dussor, Gregory; Price, Theodore J.; Pancrazio, Joseph J. (Elsevier Advanced Technology, 2018-11-13)

  The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to ...

• Hearing Healthcare in Remote or Resource-Constrained Environments 

  Swanepoel, D.; Clark, Jackie L. (Cambridge Univ Press, 2018-07-19)

  Background Hearing loss is a leading contributor to the global burden of disease, with more than 80 per cent of affected persons residing in low- and middle-income countries, typically where hearing health services are ...

• Vagus Nerve Stimulation as a Tool for Enhancing Extinction in Exposure-Based Therapies 

  Noble, Lindsey J.; Souza, Rimenez R.; McIntyre, Christa K. (Springer, 2019-01)

  Rationale Emotionally traumatic experiences can lead to maladaptive memories that are enduring and intrusive. The goal of exposure-based therapies is to extinguish conditioned fears through repeated, unreinforced exposures ...

• The Relationship Between Age, Neural Differentiation, and Memory Performance 

  Koen, Joshua D.; Hauck, Nedra; Rugg, Michael D. (Society for Neuroscience, 2018-11-02)

  Healthy aging is associated with decreased neural selectivity (dedifferentiation) in category-selective cortical regions. This finding has prompted the suggestion that dedifferentiation contributes to age-related cognitive ...

• The Antidiabetic Drug Metformin Prevents and Reverses Neuropathic Pain and Spinal Cord Microglial Activation in Male but not Female Mice 

  Inyang, Kufreobong E.; Szabo-Pardi, Thomas; Wentworth, Emma; McDougal, Timothy A.; Dussor, Gregory; Burton, Michael D.; Price, Theodore J. (Academic Press Ltd- Elsevier Science Ltd, 2018-11-01)

  Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK ...

• Tinnitus and Neuropathic Pain Share a Common Neural Substrate in the Form of Specific Brain Connectivity and Microstate Profiles 

  Vanneste, Sven; To, Wing Ting; De Ridder, Dirk (Pergamon-Elsevier Science Ltd, 2018-08-22)

  Tinnitus and neuropathic pain share similar pathophysiological, clinical, and treatment characteristics. In this EEG study, a group of tinnitus (n = 100) and neuropathic pain (n = 100) patients are compared to each other ...

• Top-Down and Bottom-Up Regulated Auditory Phantom Perception 

  Vanneste, Sven; Alsalman, Ola; De Ridder, Dirk (Soc Neuroscience, 2019-01-09)

  Auditory phantom percepts such as tinnitus are associated with auditory deafferentation. The idea is that auditory deafferentation limits the amount of information the brain can acquire to make sense of the world. Because ...

• Current Conceptualizations of Narcissism 

  Ackerman, Robert A.; Donnellan, M. Brent; Wright, Aidan G. C. (Lippincott Williams & Wilkins, 2019-01)

  Purpose of review: Definitions of narcissism have traditionally differed across psychiatry and subfields of psychology. This review aims to highlight emerging points of consensus and suggest further directions needed to ...

• Activation of the Integrated Stress Response in Nociceptors Drives Methylglyoxal-Induced Pain 

  Barragan-Iglesias, Paulino; Kuhn, Jasper; Vidal-Cantu, Guadalupe C.; Belen Salinas-Abarca, Ana; Granados-Soto, Vinicio; Dussor, Gregory; Campbell, Zachary T.; Price, Theodore J. (Lippincott Williams & Wilkins, 2019-01)

  Methylglyoxal (MGO) is a reactive glycolytic metabolite associated with painful diabetic neuropathy at plasma concentrations between 500 nM and 5 μM. The mechanisms through which MGO causes neuropathic pain at these ...

• First Impressions of Adults with Autism Improve with Diagnostic Disclosure and Increased Autism Knowledge of Peers 

  Sasson, Noah J.; Morrison, Kerrianne E. (Sage Publications Ltd, 2017-10-17)

  A practical consideration for many intellectually able adults with autism spectrum disorder (ASD) is whether to disclose their diagnostic status or try to mask their autistic characteristics to avoid judgment and discrimination. ...

• Vagus Nerve Stimulation Promotes Generalization of Conditioned Fear Extinction and Reduces Anxiety in Rats 

  Noble, Lindsey J.; Meruva, Venkat B.; Hays, Seth A.; Rennaker, Robert L.; Kilgard, Michael P.; McIntyre, Christa K. (Elsevier Science Inc, 2018-09-21)

  Background: Exposure-based therapies are used to treat a variety of trauma- and anxiety-related disorders by generating successful extinction following cue exposure during treatment. The development of adjuvant strategies ...

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