• Pairing Sound with Vagus Nerve Stimulation Modulates Cortical Synchrony and Phase Coherence in Tinnitus: An Exploratory Retrospective Study 

  Vanneste, Sven; Martin, Jeffrey S.; Rennaker, Robert L.; Kilgard, Michael P.

  Recent research has shown that vagus nerve stimulation (VNS) paired with tones or with rehabilitative training can help patients to achieve reductions in tinnitus perception or to expedite motor rehabilitation after suffering ...

• 17-β-Estradiol Induces Spreading Depression and Pain Behavior in Alert Female Rats 

  Sandweiss, Alexander J.; Cottier, Karissa E.; McIntosh, Mary I.; Dussor, Gregory; Davis, Thomas P.; Vanderah, Todd W.; Largent-Milnes, Tally M.

  Aims: Test the putative contribution of 17-β-estradiol in the development of spreading depression (SD) events and head pain in awake, non-restrained rats. Main Methods: Female, Sprague-Dawley rats were intact or underwent ...

• A Critical Role for Dopamine D5 Receptors in Pain Chronicity in Male Mice 

  Megat, Salim; Shiers, Stephanie; Moy, Jamie K.; Barragan-Iglesias, Paulino; Pradhan, Grishma; Megat, Salim; Dussor, Gregory; Price, Theodore J.

  Dopaminergic modulation of spinal cord plasticity has long been recognized, but circuits affected by this system and the precise receptor subtypes involved in this modulation have not been defined. Dopaminergic modulation ...

• eIF4E Phosphorylation Influences BDNF mRNA Translation in Mouse Dorsal Root Ganglion Neurons 

  Moy, Jamie K.; Khoutorsky, Arkady; Asiedu, Marina N.; Dussor, Gregory; Price, Theodore J.

  Plasticity in dorsal root ganglion (DRG) neurons that promotes pain requires activity-dependent mRNA translation. Protein synthesis inhibitors block the ability of many pain-promoting molecules to enhance excitability in ...

• The Neural Correlates of the Unified Percept of Alcohol-Related Craving: A fMRI and EEG Study 

  Huang, Yuefeng; Mohan, Anusha; De Ridder, Dirk; Sunaert, Stefan; Vanneste, Sven

  Alcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in ...

• Bi-Modal Stimulation in the Treatment of Tinnitus: A Study Protocol for an Exploratory Trial to Optimise Stimulation Parameters and Patient Subtyping 

  D'Arcy, Shona; Hamilton, Caroline; Hughes, Stephen; Hall, Deborah A.; Vanneste, Sven; Langguth, Berthold; Conlon, Brendan

  INTRODUCTION: Tinnitus is the perception of sound in the absence of a corresponding external acoustic stimulus. Bimodal neuromodulation is emerging as a promising treatment for this condition. The main objectives of this ...

• Higher-Order Cognitive Training Effects on Processing Speed-Related Neural Activity: A Randomized Trial 

  Yezhuvath, Uma S.; Aslan, Sina; Motes, Michael A.; Spence, Jeffrey S.; Rypma, Bart; Chapman, Sandra Bond

  Higher-order cognitive training has shown to enhance performance in older adults, but the neural mechanisms underlying performance enhancement have yet to be fully disambiguated. This randomized trial examined changes in ...

• Voice Gender and the Segregation of Competing Talkers: Perceptual Learning in Cochlear Implant Simulations 

  Sullivan, J. R.; Assmann, Peter F.; Hossain, Shaikat; Schafer, Erin C.

  Two experiments explored the role of differences in voice gender in the recognition of speech masked by a competing talker in cochlear implant simulations. Experiment 1 confirmed that listeners with normal hearing receive ...

• Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest 

  Sweeney-Reed, Catherine M.; Zaehle, Tino; Voges, Juergen; Schmitt, Friedhelm C.; Buentjen, Lars; Borchardt, Viola; Walter, Martin; Hinrichs, Hermann; Heinze, Hans-Jochen; Rugg, Michael D.; Knight, Robert T.

  Cross-frequency coupling (CFC) between slow and fast brain rhythms, in the form of phase-amplitude coupling (PAC), is proposed to enable the coordination of neural oscillatory activity required for cognitive processing. ...

• A Quantitative Electroencephalography Study on Cochlear Implant-Induced Cortical Changes in Single-Sided Deafness with Tinnitus 

  Song, Jae-Jin; Kim, Kyungsoo; Sunwoo, Woongsang; Mertens, Griet; Van de Heyning, Paul; De Ridder, Dirk; Vanneste, Sven; Lee, Sang-Youp; Park, Kyung-Joon; Choi, Hongsoo; Choi, Ji-Woong

  The mechanism of tinnitus suppression after cochlear implantation (CI) in single-sided deafness (SSD) is not fully understood. In this regard, by comparing pre-and post-CI quantitative electroencephalography (qEEG), we ...

• Using the Single Prolonged Stress Model to Examine the Pathophysiology of PTSD 

  Souza, Rimenez R.; Noble, Lindsey J.; McIntyre, Christa K.

  The endurance of memories of emotionally arousing events serves the adaptive role of minimizing future exposure to danger and reinforcing rewarding behaviors. However, following a traumatic event, a subset of individuals ...

• Antioxidant Treatment with N-acetyl Cysteine Prevents the Development of Cognitive and Social Behavioral Deficits That Result from Perinatal Ketamine Treatment 

  Phensy, Aarron; Duzdabanian, Hasmik E.; Brewer, Samantha; Panjabi, Anurag; Driskill, Christopher; Berz, Annuska; Peng, George; Kroener, Sven

  Alterations of the normal redox state can be found in all stages of schizophrenia, suggesting a key role for oxidative stress in the etiology and maintenance of the disease. Pharmacological blockade of N-methyl-D-aspartic ...

• The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain 

  Moy, Jamie K.; Khoutorsky, A.; Black, Brian J.; Kuhn, Jasper L.; Barragán-Iglesias, Paulino; Megat, Salim; Burton, Michael D.; Burgos-Vega, Carolina C.; Melemedjian, O. K.; Boitano, S.; Vagner, J.; Gkogkas, C. G.; Pancrazio, Joseph J.; Mogil, J. S.; Dussor, Gregory; Sonenberg, N.; Price, Theodore J.

  Injury-induced sensitization of nociceptors contributes to pain states and the development of chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of rapamycin and mitogen-activated protein ...

• Theta and Alpha Alterations in Amnestic Mild Cognitive Impairment in Semantic Go/NoGo Tasks 

  Nguyen, Lydia T.; Mudar, Raksha A.; Chiang, Hsueh-Sheng; Schneider, Julie M.; Maguire, Mandy J.; Kraut, Michael A.; Hart, John, Jr.

  Growing evidence suggests that cognitive control processes are impaired in amnestic mild cognitive impairment (aMCI); however the nature of these alterations needs further examination. The current study examined differences ...

• Retinal Architecture and Melanopsin-Mediated Pupillary Response Characteristics a Putative Pathophysiologic Signature for the Retino-Hypothalamic Tract in Multiple Sclerosis 

  Meltzer, Ethan; Sguigna, Peter V.; Subei, Adnan; Beh, Shin; Kildebeck, Eric; Conger, Darrel; Conger, Amy; Lucero, Marlen; Frohman, Benjamin S.; Frohman, Ashley N.; Saidha, Shiv; Galetta, Steven; Calabresi, Peter A.; Rennaker, Robert; Frohman, Teresa C.; Kardon, Randy H.; Balcer, Laura J.; Frohman, Elliot M.

  IMPORTANCE A neurophysiologic signature of the melanopsin-mediated persistent constriction phase of the pupillary light reflex may represent a surrogate biomarker for the integrity of the retinohypothalamic tract, with ...

• Effects of Vagus Nerve Stimulation on Extinction of Conditioned Fear and Post-Traumatic Stress Disorder Symptoms in Rats 

  Noble, Lindsey J.; Gonzalez, I. J.; Meruva, V. B.; Callahan, Kathleen A.; Belfort, Benjamin D.; Ramanathan, K. R.; Meyers, Eric; Kilgard, Michael P.; Rennaker, Robert L.; McIntyre, Christa K.

  Exposure-based therapies help patients with post-traumatic stress disorder (PTSD) to extinguish conditioned fear of trauma reminders. However, controlled laboratory studies indicate that PTSD patients do not extinguish ...

• Modulation of Oscillatory Power and Connectivity in the Human Posterior Cingulate Cortex Supports the Encoding and Retrieval of Episodic Memories 

  Lega, Bradley; Germi, James; Rugg, Michael D.

  Existing data from noninvasive studies have led researchers to posit that the posterior cingulate cortex (PCC) supports mnemonic processes: It exhibits degeneration in memory disorders, and fMRI investigations have ...

• Hidden Hearing Loss? No Effect of Common Recreational Noise Exposure on Cochlear Nerve Response Amplitude in Humans 

  Grinn, Sarah K.; Wiseman, Kathryn B.; Baker, Jason A.; Le Prell, Colleen G.

  This study tested hypothesized relationships between noise exposure and auditory deficits. Both retrospective assessment of potential associations between noise exposure history and performance on an audiologic test battery ...

• Differential Aging Trajectories of Modulation of Activation to Cognitive Challenge in APOEε4 Groups: Reduced Modulation Predicts Poorer Cognitive Performance 

  Foster, Chris M.; Kennedy, Kristen M.; Rodrigue, Karen M.

  The present study was designed to investigate the effect of a genetic risk factor for Alzheimer's disease (AD), ApolipoproteinE ε4 (APOEε4), on the ability of the brain to modulate activation in response to cognitive ...

• Using Electromagnetic Articulography with a Tongue Lateral Sensor to Discriminate Manner of Articulation 

  Katz, William F.; Mehta, Sonya; Wood, Matthew; Wang, Jun

  This study examined the contributions of the tongue tip (TT), tongue body (TB), and tongue lateral (TL) sensors in the electromagnetic articulography (EMA) measurement of American English alveolar consonants. Thirteen ...

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