• Neural Mechanisms of Behavioral Change in Young Adults with High-Functioning Autism Receiving Virtual Reality Social Cognition Training: A Pilot Study 

  Yang, Y. J. Daniel; Allen, Tandra; Abdullahi, Sebiha M.; Pelphrey, Kevin A.; Volkmar, Fred R.; Chapman, Sandra Bond

  Measuring treatment efficacy in individuals with Autism Spectrum Disorder (ASD) relies primarily on behaviors, with limited evidence as to the neural mechanisms underlying these behavioral gains. This pilot study addresses ...

• Which Levels of Cognitive Impairments and Negative Symptoms Are Related to Functional Deficits in Schizophrenia? 

  Strassnig, M.; Bowie, C.; Pinkham, Amy E.; Penn, D.; Twamley, E. W.; Patterson, T. L.; Harvey, P. D.

  Background: Negative symptoms and cognitive impairments predict difficulties in aspects of everyday functioning in schizophrenia, with little research to date attempting to determine if there are threshold levels of ...

• Preschoolers Sometimes Seek Help from Socially Engaged Informants over Competent Ones 

  Rowles, Sydney P.; Mills, Candice M.

  The current studies examine whether children can selectively seek help from more competent others to solve simple problems. Across two experiments, 4- and 5-year-old children watched two adults demonstrate using a toy: one ...

• Spinal Inhibition of P2XR or p38 Signaling Disrupts Hyperalgesic Priming in Male, but not Female, Mice 

  Paige, Candler; Maruthy, Gayathri B.; Mejia, Galo; Dussor, Gregory; Price, Theodore J.

  Recent studies have demonstrated sexual dimorphisms in the mechanisms contributing to the development of chronic pain. Here we tested the hypothesis that microglia might preferentially regulate hyperalgesic priming in male ...

• Optimization of Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex for Tinnitus: A Non-Linear Dose-Response Effect 

  Shekhawat, Giriraj Singh; Vanneste, Sven; Shekhawat, Giriraj Singh

  Neuromodulation is defined as the process of augmenting neuroplasticity via invasive or non-invasive methods. Tinnitus is the perception of sound in the absence of its external source. The objective of this study was to ...

• Transcranial Magnetic Stimulation of the Left Angular Gyrus During Encoding Does not Impair Associative Memory Performance 

  Koen, Joshua D.; Thakral, P. P.; Rugg, Michael D.

  The left angular gyrus (AG) is thought to play a critical role in episodic retrieval and has been implicated in the recollection of specific details of prior episodes. Motivated by recent fMRI studies in which it was ...

• Social Cognitive Impairments in Individuals with Schizophrenia Vary in Severity 

  Hajdúk, M.; Harvey, P. D.; Penn, D. L.; Pinkham, Amy E.

  Social cognitive deficits are a hallmark feature of schizophrenia and have been confirmed by several meta-analyses; however, the uniformity of these impairments across individuals remains unknown. The present study evaluated ...

• Targeted Acid-Sensing Ion Channel Therapies for Migraine 

  Karsan, Nazia; Gonzales, Eric B.; Dussor, Gregory

  Acid-sensing ion channels (ASICs) are a family of ion channels, consisting of four members; ASIC1 to 4. These channels are sensitive to changes in pH and are expressed throughout the central and peripheral nervous ...

• Influencing Connectivity and Cross-Frequency Coupling by Real-Time Source Localized Neurofeedback of the Posterior Cingulate Cortex Reduces Tinnitus Related Distress 

  Vanneste, Sven; Joos, Kathleen; Ost, Jan; De Ridder, Dirk

  Background: In this study we are using source localized neurofeedback to moderate tinnitus related distress by influencing neural activity of the target region as well as the connectivity within the default network. ...

• Haptic Stroke Testbed for Pharmacological Evaluation of Dynamic Allodynia in Mouse Models 

  Lee, Jin; Atwood, Brian J.; Megat, Salim; Dussor, Gregory; Price, Theodore J.; Fey, Ann Majewicz

  Dynamic mechanical allodynia is an aggravating neuropathological condition in which light, physical touch leads to pain. Developing pharmaceutical agents to treat this condition requires extensive animal trials using a ...

• Increased Social Cognitive Bias in Subclinical Paranoia 

  Klein, Hans S.; Kelsven, S.; Pinkham, Amy E.

  This article has no abstract. Following is the first paragraph: "Recent initiatives have shifted the emphasis from studying pathological illnesses as separate diagnostic entities to examining specific symptoms on a continuum ...

• Functional Magnetic Neuroimaging Data on Age-Related Differences in Task Switching Accuracy and Reverse Brain-Behavior Relationships 

  Basak, Chandramallika; Qin, Shou; Nashiro, K.; O'Connell, Margaret A.

  The data presented in this article is related to the research article entitled “Age-related Differences in BOLD Modulation to Cognitive Control Costs in a Multitasking Paradigm: Global Switch, Local Switch, and ...

• Three‐Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis 

  Sivakolundu, Dinesh K.; Hansen, Madison R.; West, Kathryn L.; Wang, Yeqi; Stanley, Thomas; Wilson, Andrew; McCreary, Morgan; Turner, Monroe P.; Pinho, Marco C.; Newton, Braeden D.; Guo, Xiaohu; Rypma, Bart; Okuda, Darin T.

  BACKGROUND AND PURPOSE Multiple sclerosis (MS) clinical management is based upon lesion characterization from 2‐dimensional (2D) magnetic resonance imaging (MRI) views. Such views fail to convey the lesion‐phenotype (ie, ...

• Evolution of Chemokine Receptors Is Driven by Mutations in the Sodium Binding Site 

  Taddese, B.; Deniaud, M.; Garnier, A.; Tiss, A.; Guissouma, H.; Abdi, Hervé; Henrion, D.; Chabbert, M.

  Chemokines and their receptors (members of the GPCR super-family) are involved in a wide variety of physiological processes and diseases; thus, understanding the specificity of the chemokine receptor family could help ...

• The Impact of Brief Restriction to Articulation on Children's Subsequent Speech Production 

  Seidl, Amanda; Brosseau-Lapré, Françoise; Goffman, Lisa

  This project explored whether disruption of articulation during listening impacts subsequent speech production in 4-yr-olds with and without speech sound disorder (SSD). During novel word learning, typically-developing ...

• A Multilevel Computational Characterization of Endophenotypes in Addiction 

  Fiore, Vincenzo G.; Ognibene, D.; Adinoff, B.; Gu, Xiaosi

  Addiction is characterized by a profound intersubject (phenotypic) variability in the expression of addictive symptomatology and propensity to relapse following treatment. However, laboratory investigations have primarily ...

• Socioeconomic Status Moderates Age-Related Differences in the Brain's Functional Network Organization and Anatomy Across the Adult Lifespan 

  Chan, Micaela Y.; Na, Jinkyung; Agres, Phillip F.; Savalia, Neil K.; Park, Denise C.; Wig, Gagan S.

  An individual's environmental surroundings interact with the development and maturation of their brain. An important aspect of an individual's environment is his or her socioeconomic status (SES), which estimates access ...

• Cortical Map Plasticity as a Function of Vagus Nerve Stimulation Rate 

  Buell, Elizabeth P.; Loerwald, Kristofer W.; Engineer, Crystal T.; Borland, Michael S .; Buell, John M.; Kelly, C. A.; Khan, I. I.; Hays, Seth A.; Kilgard, Michael P.

  Background: Repeatedly pairing a brief train of vagus nerve stimulation (VNS) with an external event can reorganize the sensory or motor cortex. A 30 Hz train of sixteen VNS pulses paired with a tone significantly increases ...

• Adolescents Show Differential Dysfunctions Related to Alcohol and Cannabis Use Disorder Severity in Emotion and Executive Attention Neuro-Circuitries 

  Aloi, J.; Blair, K. S.; Crum, K. I.; Meffert, H.; White, S. F.; Tyler, P. M.; Thornton, L. C.; Mobley, A. M.; Killanin, A. D.; Adams, K. O.; Filbey, Francesca M.; Pope, K.; Blair, R. J. R.

  Alcohol and cannabis are two substances that are commonly abused by adolescents in the United States and which, when abused, are associated with negative medical and psychiatric outcomes across the lifespan. These negative ...

• Longitudinal Associations between Family Members' Internalizing Symptoms across Middle Childhood 

  Villarreal, Deyaun L.; Nelson, Jackie A.

  An individual's internalizing symptoms have been shown to relate to greater symptoms in family members. However, an examination of how family members' symptoms are associated with one another is needed with a model including ...

View more