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dc.contributor.authorShokri-Kojori, Ehsanen_US
dc.contributor.authorMotes, Michael A.en_US
dc.contributor.authorRypma, Barten_US
dc.contributor.authorKrawczyk, Daniel C.en_US
dc.description.abstractReasoning processes have been closely associated with prefrontal cortex (PFC), but specifically emerge from interactions among networks of brain regions. Yet it remains a challenge to integrate these brain-wide interactions in identifying the flow of processing emerging from sensory brain regions to abstract processing regions, particularly within PFC. Functional magnetic resonance imaging data were collected while participants performed a visuo-spatial reasoning task. We found increasing involvement of occipital and parietal regions together with caudal-rostral recruitment of PFC as stimulus dimensions increased. Brain-wide connectivity analysis revealed that interactions between primary visual and parietal regions predominantly influenced activity in frontal lobes. Caudal-to-rostral influences were found within left-PFC. Right-PFC showed evidence of rostral-to-caudal connectivity in addition to relatively independent influences from occipito-parietal cortices. In the context of hierarchical views of PFC organization, our results suggest that a caudal-to-rostral flow of processing may emerge within PFC in reasoning tasks with minimal top-down deductive requirements.en_US
dc.rightsCC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)en_US
dc.rights©2012 The Authors.en_US
dc.subjectFrontal Lobeen_US
dc.subjectPrefrontal Cortexen_US
dc.subjectShort-term memoryen_US
dc.titleThe Network Architecture of Cortical Processing in Visuo-Spatial Reasoningen_US
dc.contributor.sponsorSchool of Behavioral and Brain Sciences. Center for BrainHealth.en_US
dc.identifier.bibliographicCitationShokri-Kojori, E., M. A. Motes, B. Rypma, and D. C. Krawczyk. 2012. "The network architecture of cortical processing in visuo-spatial reasoning." Scientific Reports 2 (411).en_US
dc.source.journalScientific Reportsen_US

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CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
Except where otherwise noted, this item's license is described as CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)