McIntyre-Rodriguez, Christa
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Dr. McIntyre-Rodriguez's research is aimed at gaining information regarding the neuronal signals that determine whether a memory will be stored for the long term and may shed some light on the precise mechanisms involved in the synaptic changes that underlie memory. Such knowledge may ultimately be used to benefit individuals suffering from various memory disorders including Alzheimer's disease and post traumatic stress disorder.
Learn more about Christa McIntyre-Rodriguez on her BBS People and Research Explorer pages.
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Recent Submissions
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Vagus Nerve Stimulation as a Tool for Enhancing Extinction in Exposure-Based Therapies
(Springer, 2019-01)Rationale Emotionally traumatic experiences can lead to maladaptive memories that are enduring and intrusive. The goal of exposure-based therapies is to extinguish conditioned fears through repeated, unreinforced exposures ... -
Vagus Nerve Stimulation Promotes Generalization of Conditioned Fear Extinction and Reduces Anxiety in Rats
(Elsevier Science Inc, 2018-09-21)Background: Exposure-based therapies are used to treat a variety of trauma- and anxiety-related disorders by generating successful extinction following cue exposure during treatment. The development of adjuvant strategies ... -
Vagus Nerve Stimulation Reverses the Extinction Impairments in a Model of PTSD with Prolonged and Repeated Trauma
(Taylor and Francis Ltd, 2019-04-23)We have shown that vagus nerve stimulation (VNS) enhances extinction of conditioned fear and reduces anxiety in rat models of PTSD using moderate stress. However, it is still unclear if VNS can be effective in enhancing ... -
Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning
Although evidence suggests that the basolateral amygdala (BLA) and dorsal hippocampus (DH) work together to influence the consolidation of spatial/contextual learning, the circuit mechanism by which the BLA selectively ... -
Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning
Although evidence suggests that the basolateral amygdala (BLA) and dorsal hippocampus (DH) work together to influence the consolidation of spatial/contextual learning, the circuit mechanism by which the BLA selectively ... -
Using the Single Prolonged Stress Model to Examine the Pathophysiology of PTSD
The endurance of memories of emotionally arousing events serves the adaptive role of minimizing future exposure to danger and reinforcing rewarding behaviors. However, following a traumatic event, a subset of individuals ... -
Effects of Vagus Nerve Stimulation on Extinction of Conditioned Fear and Post-Traumatic Stress Disorder Symptoms in Rats
Exposure-based therapies help patients with post-traumatic stress disorder (PTSD) to extinguish conditioned fear of trauma reminders. However, controlled laboratory studies indicate that PTSD patients do not extinguish ... -
Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-Traumatic Stress Disorder
High levels of emotional arousal can impair spatial memory mediated by the hippocampus, and enhance stimulus-response (S-R) habit memory mediated by the dorsolateral striatum (DLS). The present study was conducted to ... -
Memory-Enhancing Intra-Basolateral Amygdala Infusions of Clenbuterol Increase Arc and Camkiiα Protein Expression in the Rostral Anterior Cingulate Cortex
Activation of β-adrenoceptors in the basolateral complex of the amygdala (BLA) modulates memory through interactions with multiple memory systems. The cellular mechanisms for this interaction remain unresolved. Memory-modulating ...
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