Now showing items 1-3 of 3
Miror: A Method for Cell-Type Specific MicroRNA Occupancy Rate Prediction
(Royal Soc Chemistry, 2014-03-13)
MicroRNA (miRNA) regulation is highly cell-type specific. It is sensitive to both the miRNA-mRNA relative abundance and the competitive endogenous RNA (ceRNA) effect. However, almost all existing miRNA target prediction ...
Hsa-miR-1246, Hsa-miR-320a and Hsa-miR-196b-5p Inhibitors can Reduce the Cytotoxicity of Ebola Virus Glycoprotein in Vitro
(Science Press, 2014-09-12)
Ebola virus (EBOV) causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91% in Zaire, the most lethal strain. Though the viral envelope glycoprotein (GP) mediates ...
Histone Deacetylases Positively Regulate Transcription Through the Elongation Machinery
(Elsevier B.V., 2015-11-17)
Transcription elongation regulates the expression of many genes, including oncogenes. Histone deacetylase (HDAC) inhibitors (HDACIs) block elongation, suggesting that HDACs are involved in gene activation. To understand ...