Now showing items 17-21 of 21

    • OLego: Fast and Sensitive Mapping of Spliced mRNA-Seq Reads Using Small Seeds 

      Wu, Jie; Anczuk©w, Olga; Krainer, Adrian R.; Zhang, Michael Q.; Zhang, Chaolin (Oxford University Press, 2013-04)
      A crucial step in analyzing mRNA-Seq data is to accurately and efficiently map hundreds of millions of reads to the reference genome and exon junctions. Here we present OLego, an algorithm specifically designed for de novo ...
    • Prediction of High-Risk Types of Human Papillomaviruses Using Statistical Model of Protein “Sequence Space” 

      Wang, C.; Hai, Y.; Liu, X.; Liu, N.; Yao, Y.; He, P.; Dai, Qi (Hindawi Publishing Corporation, 2015-03-21)
      Discrimination of high-risk types of human papillomaviruses plays an important role in the diagnosis and remedy of cervical cancer. Recently, several computational methods have been proposed based on protein sequence-based ...
    • Quantitative liver-specific protein fingerprint in blood: A signature for hepatotoxicity 

      Hu, Z.; Lausted, C.; Yoo, Hyuntae; Yan, X.; Brightman, A.; Chen, J.; Wang, W.; Bu, X.; Hood, L. (2014-01-14)
      We discuss here a new approach to detecting hepatotoxicity by employing concentration changes of liver-specific blood proteins during disease progression. These proteins are capable of assessing the behaviors of their ...
    • Synthetic Mammalian Transgene Negative Autoregulation 

      Shimoga, Vinay; White, Jacob T.; Li, Yi; Sontag, Eduardo; Bleris, Leonidas (2013-06-04)
      Biological networks contain overrepresented small-scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative-feedback loop, where a gene product represses its own transcription. ...
    • Transcripts for Combined Synthetic MicroRNA and Gene Delivery 

      Kashyap, Neha; Pham, Bich; Xie, Zhen; Bleris, Leonidas (2013-06-26)
      MicroRNAs (miRNAs) are a class of short noncoding RNAs which are endogenously expressed in many organisms and regulate gene expression by binding to messenger RNA (mRNA). MicroRNAs are either produced from their independent ...