Now showing items 20-21 of 21

    • Synthetic Mammalian Transgene Negative Autoregulation 

      Shimoga, Vinay; White, Jacob T.; Li, Yi; Sontag, Eduardo; Bleris, Leonidas (2013-06-04)
      Biological networks contain overrepresented small-scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative-feedback loop, where a gene product represses its own transcription. ...
    • Transcripts for Combined Synthetic MicroRNA and Gene Delivery 

      Kashyap, Neha; Pham, Bich; Xie, Zhen; Bleris, Leonidas (2013-06-26)
      MicroRNAs (miRNAs) are a class of short noncoding RNAs which are endogenously expressed in many organisms and regulate gene expression by binding to messenger RNA (mRNA). MicroRNAs are either produced from their independent ...