Now showing items 1-2 of 2

    • Engineering Repressors with Coevolutionary Cues Facilitates Toggle Switches with a Master Reset 

      Dimas, R. P.; Jiang, Xian-Li; Alberto de la Paz, Jose; Morcos, Faruck; Chan, C. T. Y. (Oxford University Press, 2019-04-24)
      Engineering allosteric transcriptional repressors containing an environmental sensing module (ESM) and a DNA recognition module (DRM) has the potential to unlock a combinatorial set of rationally designed biological ...
    • Synthetic Mammalian Transgene Negative Autoregulation 

      Shimoga, Vinay; White, Jacob T.; Li, Yi; Sontag, Eduardo; Bleris, Leonidas (2013-06-04)
      Biological networks contain overrepresented small-scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative-feedback loop, where a gene product represses its own transcription. ...