Now showing items 1-2 of 2
Synthetic Mammalian Transgene Negative Autoregulation
Biological networks contain overrepresented small-scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative-feedback loop, where a gene product represses its own transcription. ...
Engineering Repressors with Coevolutionary Cues Facilitates Toggle Switches with a Master Reset
(Oxford University Press, 2019-04-24)
Engineering allosteric transcriptional repressors containing an environmental sensing module (ESM) and a DNA recognition module (DRM) has the potential to unlock a combinatorial set of rationally designed biological ...