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    Exploiting the CRISPR/Cas9 PAM Constraint for Single-Nucleotide Resolution Interventions 

    Li, Yi; Mendiratta, Saurabh; Ehrhardt, Kristina; Kashyap, Neha; White, Michael A.; Bleris, Leonidas (2016-01-20)
    CRISPR/Cas9 is an enabling RNA-guided technology for genome targeting and engineering. An acute DNA binding constraint of the Cas9 protein is the Protospacer Adjacent Motif (PAM). Here we demonstrate that the PAM requirement ...
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    Assembly and Validation of Versatile Transcription Activator-Like Effector Libraries 

    Li, Yi; Ehrhardt, Kristina; Zhang, Michael Q.; Bleris, Leonidas (Nature Publishing Group, 2014-05-06)
    The ability to perturb individual genes in genome-wide experiments has been instrumental in unraveling cellular and disease properties. Here we introduce, describe the assembly, and demonstrate the use of comprehensive and ...

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    AuthorBleris, Leonidas (2)
    Ehrhardt, Kristina (2)
    Li, Yi (2)Kashyap, Neha (1)Mendiratta, Saurabh (1)White, Michael A. (1)Zhang, Michael Q. (1)SubjectDNA (2)Bait sequences (1)Cas9 protein, Francisella novicida (1)Codon (1)KRAS protein, human (1)Multidrug resistance (1)Mutation (1)Plasmids (1)RNA, Guide (1)RNA, Messenger (1)... View MoreDate Issued2014 (1)2016 (1)Has File(s)Yes (2)

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