Now showing items 1-1 of 1
Exploiting the CRISPR/Cas9 PAM Constraint for Single-Nucleotide Resolution Interventions
CRISPR/Cas9 is an enabling RNA-guided technology for genome targeting and engineering. An acute DNA binding constraint of the Cas9 protein is the Protospacer Adjacent Motif (PAM). Here we demonstrate that the PAM requirement ...