Center for Vital Longevity
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Founded in 2010, and led by co-directors Dr. Denise Park and Dr. Michael Rugg, the center brings together an extraordinary group of research scientists who are using advanced brain-imaging technologies and research techniques in cognitive neuroscience to understand, maintain and improve the vitality of the aging mind. Their focus holds particular importance to our society, which has a higher proportion of older adults than ever before. More information about the Center is available here.
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Gamma Oscillations During Episodic Memory Processing Provide Evidence for Functional Specialization in the Longitudinal Axis of the Human Hippocampus
(Wiley, 2018-11-05)The question of whether the anterior and posterior hippocampus serve different or complementary functional roles during episodic memory processing has been motivated by noteworthy findings in rodent experiments and from ... -
ASL-MRICloud: An Online Tool for the Processing of ASL MRI Data
(Wiley, 2018-12-26)Arterial spin labeling (ASL) MRI is increasingly used in research and clinical settings. The purpose of this work is to develop a cloud-based tool for ASL data processing, referred to as ASL-MRICloud, which may be useful ... -
Frontostriatal White Matter Connectivity: Age Differences and Associations with Cognition and BOLD Modulation
(Elsevier Inc., 2020-06-07)Despite the importance of cortico-striatal circuits to cognition, investigation of age effects on the structural circuitry connecting these regions is limited. The current study examined age effects on frontostriatal white ... -
Genetic Predisposition for Inflammation Exacerbates Effects of Striatal Iron Content on Cognitive Switching Ability in Healthy Aging
(Academic Press Inc Elsevier Science, 2018-10-25)Non-heme iron homeostasis interacts with inflammation bidirectionally, and both contribute to age-related decline in brain structure and function via oxidative stress. Thus, individuals with genetic predisposition for ... -
The Relationship Between Age, Neural Differentiation, and Memory Performance
(Society for Neuroscience, 2018-11-02)Healthy aging is associated with decreased neural selectivity (dedifferentiation) in category-selective cortical regions. This finding has prompted the suggestion that dedifferentiation contributes to age-related cognitive ... -
Frontoparietal Cortical Thickness Mediates the Effect of COMT Val¹⁵⁸Met Polymorphism on Age-Associated Executive Function
(Elsevier Science Inc, 2018-09-21)Proper dopamine (DA) signaling is likely necessary for maintaining optimal cognitive performance as we age, particularly in prefrontal-parietal networks and in fronto-striatal networks. Thus, reduced DA availability is a ... -
Progress Update from the Hippocampal Subfields Group
(Elsevier Inc., 2019-06-13)Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to ... -
High-Fidelity Mapping of Repetition-Related Changes in the Parietal Memory Network
(Elsevier Inc., 2019-06-05)fMRI studies of human memory have identified a “parietal memory network” (PMN) that displays distinct responses to novel and familiar stimuli, typically deactivating during initial encoding but robustly activating during ... -
Learning Efficiency: Identifying Individual Differences in Learning Rate and Retention in Healthy Adults
People differ in how quickly they learn information and how long they remember it, yet individual differences in learning abilities within healthy adults have been relatively neglected. In two studies, we examined the ... -
Transcranial Magnetic Stimulation of the Left Angular Gyrus During Encoding Does not Impair Associative Memory Performance
The left angular gyrus (AG) is thought to play a critical role in episodic retrieval and has been implicated in the recollection of specific details of prior episodes. Motivated by recent fMRI studies in which it was ... -
Socioeconomic Status Moderates Age-Related Differences in the Brain's Functional Network Organization and Anatomy Across the Adult Lifespan
An individual's environmental surroundings interact with the development and maturation of their brain. An important aspect of an individual's environment is his or her socioeconomic status (SES), which estimates access ... -
Moral Judgement by the Disconnected Left and Right Cerebral Hemispheres: A Split-Brain Investigation
(2017-07-26)Owing to the hemispheric isolation resulting from a severed corpus callosum, research on split-brain patients can help elucidate the brain regions necessary and sufficient for moral judgement. Notably, typically developing ... -
Differential Aging Trajectories of Modulation of Activation to Cognitive Challenge in APOEε4 Groups: Reduced Modulation Predicts Poorer Cognitive Performance
The present study was designed to investigate the effect of a genetic risk factor for Alzheimer's disease (AD), ApolipoproteinE ε4 (APOEε4), on the ability of the brain to modulate activation in response to cognitive ... -
Are There Multiple Kinds of Episodic Memory? An fMRI Investigation Comparing Autobiographical and Recognition Memory Tasks
(Society for Neuroscience, 2018-08-20)What brain regions underlie retrieval from episodic memory? The bulk of research addressing this question with fMRI has relied upon recognition memory for materials encoded within the laboratory. Another, less dominant ... -
To Switch or Not to Switch: Role of Cognitive Control in Working Memory Training in Older Adults
It is currently not known what are the best working memory training strategies to offset the age-related declines in fluid cognitive abilities. In this randomized clinical double-blind trial, older adults were randomly ... -
Altered Cerebellar Connectivity in Parkinson's Patients ON and OFF L-DOPA Medication
(Frontiers Research Foundation, 2015-04-21)Although nigrostriatal changes are most commonly affiliated with Parkinson's disease, the role of the cerebellum in Parkinson's has become increasingly apparent. The present study used lobule-based cerebellar resting state ... -
Decreased Segregation of Brain Systems across the Healthy Adult Lifespan
Healthy aging has been associated with decreased specialization in brain function. This characterization has focused largely on describing age-accompanied differences in specialization at the level of neurons and brain ... -
Network Complexity as a Measure of Information Processing across Resting-State Networks: Evidence from the Human Connectome Project
(Frontiers Research Foundation, 2014-06-10)An emerging field of research focused on fluctuations in brain signals has provided evidence that the complexity of those signals, as measured by entropy, conveys important information about network dynamics (e.g., local ... -
Comparison of the Neural Correlates of Encoding Item-Item and Item-Context Associations
fMRI was employed to investigate the role of the left inferior frontal gyrus (LIFG) in the encoding of item-item and item-context associations. On each of a series of study trials subjects viewed a picture that was presented ... -
Age-Related Similarities and Differences in Brain Activity Underlying Reversal Learning
(2013-05-29)The ability to update associative memory is an important aspect of episodic memory and a critical skill for social adaptation. Previous research with younger adults suggests that emotional arousal alters brain mechanisms ...
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