Center for Vital Longevity
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Founded in 2010, and led by co-directors Dr. Denise Park and Dr. Michael Rugg, the center brings together an extraordinary group of research scientists who are using advanced brain-imaging technologies and research techniques in cognitive neuroscience to understand, maintain and improve the vitality of the aging mind. Their focus holds particular importance to our society, which has a higher proportion of older adults than ever before. More information about the Center is available here.
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Socioeconomic Status Moderates Age-Related Differences in the Brain's Functional Network Organization and Anatomy Across the Adult Lifespan
An individual's environmental surroundings interact with the development and maturation of their brain. An important aspect of an individual's environment is his or her socioeconomic status (SES), which estimates access ... -
Moral Judgement by the Disconnected Left and Right Cerebral Hemispheres: A Split-Brain Investigation
(2017-07-26)Owing to the hemispheric isolation resulting from a severed corpus callosum, research on split-brain patients can help elucidate the brain regions necessary and sufficient for moral judgement. Notably, typically developing ... -
Differential Aging Trajectories of Modulation of Activation to Cognitive Challenge in APOEε4 Groups: Reduced Modulation Predicts Poorer Cognitive Performance
The present study was designed to investigate the effect of a genetic risk factor for Alzheimer's disease (AD), ApolipoproteinE ε4 (APOEε4), on the ability of the brain to modulate activation in response to cognitive ... -
Are There Multiple Kinds of Episodic Memory? An fMRI Investigation Comparing Autobiographical and Recognition Memory Tasks
(Society for Neuroscience, 2018-08-20)What brain regions underlie retrieval from episodic memory? The bulk of research addressing this question with fMRI has relied upon recognition memory for materials encoded within the laboratory. Another, less dominant ... -
To Switch or Not to Switch: Role of Cognitive Control in Working Memory Training in Older Adults
It is currently not known what are the best working memory training strategies to offset the age-related declines in fluid cognitive abilities. In this randomized clinical double-blind trial, older adults were randomly ... -
Altered Cerebellar Connectivity in Parkinson's Patients ON and OFF L-DOPA Medication
(Frontiers Research Foundation, 2015-04-21)Although nigrostriatal changes are most commonly affiliated with Parkinson's disease, the role of the cerebellum in Parkinson's has become increasingly apparent. The present study used lobule-based cerebellar resting state ... -
Decreased Segregation of Brain Systems across the Healthy Adult Lifespan
Healthy aging has been associated with decreased specialization in brain function. This characterization has focused largely on describing age-accompanied differences in specialization at the level of neurons and brain ... -
Network Complexity as a Measure of Information Processing across Resting-State Networks: Evidence from the Human Connectome Project
(Frontiers Research Foundation, 2014-06-10)An emerging field of research focused on fluctuations in brain signals has provided evidence that the complexity of those signals, as measured by entropy, conveys important information about network dynamics (e.g., local ... -
Comparison of the Neural Correlates of Encoding Item-Item and Item-Context Associations
fMRI was employed to investigate the role of the left inferior frontal gyrus (LIFG) in the encoding of item-item and item-context associations. On each of a series of study trials subjects viewed a picture that was presented ... -
Age-Related Similarities and Differences in Brain Activity Underlying Reversal Learning
(2013-05-29)The ability to update associative memory is an important aspect of episodic memory and a critical skill for social adaptation. Previous research with younger adults suggests that emotional arousal alters brain mechanisms ...
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