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dc.contributor.authorNashiro, Kaoruen_US
dc.contributor.authorSakaki, Michikoen_US
dc.contributor.authorNga, Linen_US
dc.contributor.authorMather, Maraen_US
dc.identifier.citationNashiro, Kaoru, Michiko Sakaki, Lin Nga, and Mara Mather. 2013. "Age-related similarities and differences in brain activity underlying reversal learning." Frontiers In Integrative Neuroscience 7: 37-37.en_US
dc.description.abstractThe ability to update associative memory is an important aspect of episodic memory and a critical skill for social adaptation. Previous research with younger adults suggests that emotional arousal alters brain mechanisms underlying memory updating; however, it is unclear whether this applies to older adults. Given that the ability to update associative information declines with age, it is important to understand how emotion modulates the brain processes underlying memory updating in older adults. The current study investigated this question using reversal learning tasks, where younger and older participants (age ranges 19-35 and 61-78, respectively) learn a stimulus-outcome association and then update their response when contingencies change. We found that younger and older adults showed similar patterns of activation in the frontopolar OFC and the amygdala during emotional reversal learning. In contrast, when reversal learning did not involve emotion, older adults showed greater parietal cortex activity than did younger adults. Thus, younger and older adults show more similarities in brain activity during memory updating involving emotional stimuli than during memory updating not involving emotional stimuli.;en_US
dc.description.sponsorshipNational Institute on Aging grants R01AG025340, K02AG032309 and 5T32AG000037en_US
dc.rightsCC BY 3.0 (Attribution)en_US
dc.rights©2013 The Authorsen_US
dc.subjectAmygdaloid bodyen_US
dc.subjectReversal learningen_US
dc.subjectOlder peopleen_US
dc.subjectMemory disorders in old ageen_US
dc.titleAge-Related Similarities and Differences in Brain Activity Underlying Reversal Learningen_US
dc.source.journalFrontiers in Integrative Neuroscienceen_US

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