A Europium(Ⅲ)-Based PARACEST Agent for Sensing Singlet Oxygen by MRI

item.page.doi

Abstract

A europium(Ⅲ) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (¹O₂). The water soluble, thermodynamically stable complex reacts rapidly with ¹O₂ to form an endoperoxide derivative that results in an ~3 ppm shift in the position of the Eu(Ⅲ)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.;

Description

Includes supplementary material.

Keywords

Active oxygen, Magnetic resonance imaging, Chemical Exchange Saturation Transfer (CEST)

item.page.sponsorship

Rights

©2013 The Royal Society of Chemistry. This article may not be further made available or distributed.

Citation