A Europium(Ⅲ)-Based PARACEST Agent for Sensing Singlet Oxygen by MRI
Kiefer, Garry E.
Sherry, A. Dean
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A europium(Ⅲ) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (¹O₂). The water soluble, thermodynamically stable complex reacts rapidly with ¹O₂ to form an endoperoxide derivative that results in an ~3 ppm shift in the position of the Eu(Ⅲ)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.;
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