A Europium(Ⅲ)-Based PARACEST Agent for Sensing Singlet Oxygen by MRI
Date
2013-04-04
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Abstract
A europium(Ⅲ) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (¹O₂). The water soluble, thermodynamically stable complex reacts rapidly with ¹O₂ to form an endoperoxide derivative that results in an ~3 ppm shift in the position of the Eu(Ⅲ)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.;
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Includes supplementary material.
Keywords
Active oxygen, Magnetic resonance imaging, Chemical Exchange Saturation Transfer (CEST)
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©2013 The Royal Society of Chemistry. This article may not be further made available or distributed.