Browsing Price, Theodore J. by Title
Now showing items 1-17 of 17
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Activation of the Integrated Stress Response in Nociceptors Drives Methylglyoxal-Induced Pain
(Lippincott Williams & Wilkins, 2019-01)Methylglyoxal (MGO) is a reactive glycolytic metabolite associated with painful diabetic neuropathy at plasma concentrations between 500 nM and 5 μM. The mechanisms through which MGO causes neuropathic pain at these ... -
The Anti-Diabetic Drug Metformin Protects Against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model
Chemotherapy-induced peripheral neuropathy (CIPN) characterized by loss of sensory sensitivity and pain in hands and feet is the major dose-limiting toxicity of many chemotherapeutics. At present, there are no FDA-approved ... -
A Critical Role for Dopamine D5 Receptors in Pain Chronicity in Male Mice
Dopaminergic modulation of spinal cord plasticity has long been recognized, but circuits affected by this system and the precise receptor subtypes involved in this modulation have not been defined. Dopaminergic modulation ... -
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models
(Society for Neuroscience, 2019-05-29)Migraine is the second leading cause for disability worldwide and the most common neurological disorder. It is also three times more common in women; reasons for this sex difference are not known. Using preclinical behavioral ... -
eIF4E Phosphorylation Influences BDNF mRNA Translation in Mouse Dorsal Root Ganglion Neurons
Plasticity in dorsal root ganglion (DRG) neurons that promotes pain requires activity-dependent mRNA translation. Protein synthesis inhibitors block the ability of many pain-promoting molecules to enhance excitability in ... -
Emerging Neurotechnology for Antinoceptive Mechanisms and Therapeutics Discovery
(Elsevier Advanced Technology, 2018-11-13)The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to ... -
Extracellular Phosphorylation of a Receptor Tyrosine Kinase Controls Synaptic Localization of NMDA Receptors and Regulates Pathological Pain
Extracellular phosphorylation of proteins was suggested in the late 1800s when it was demonstrated that casein contains phosphate. More recently, extracellular kinases that phosphorylate extracellular serine, threonine, ... -
Haptic Stroke Testbed for Pharmacological Evaluation of Dynamic Allodynia in Mouse Models
Dynamic mechanical allodynia is an aggravating neuropathological condition in which light, physical touch leads to pain. Developing pharmaceutical agents to treat this condition requires extensive animal trials using a ... -
The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain
Injury-induced sensitization of nociceptors contributes to pain states and the development of chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of rapamycin and mitogen-activated protein ... -
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain
(Soc Neuroscience, 2019-01-16)Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including ... -
Non-Invasive Dural Stimulation in Mice: A Novel Preclinical Model of Migraine
(Sage Publications Ltd, 2018-05-31)Background Migraine is characterized by a collection of neurological symptoms in the absence of injury or damage. However, several common preclinical migraine models require significant damage to the skull to stimulate the ... -
Oestrogen Receptors Interact with the α-Catalytic Subunit of AMP-Activated Protein Kinase
Normal and pathological stressors engage the AMP-activated protein kinase (AMPK) signaling axis to protect the cell from energetic pressures. Sex steroid hormones also play a critical role in energy metabolism and significantly ... -
Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-Like Phenotypes
Fragile X syndrome (FXS) is the leading genetic cause of autism. Mutations in Fmr1 (fragile X mental retardation 1 gene) engender exaggerated translation resulting in dendritic spine dysmorphogenesis, synaptic plasticity ... -
Protease Activated Receptor 2 (PAR2) Activation Causes Migraine-Like Pain Behaviors in Mice
(Sage Publications Ltd, 2018-05-31)Background Pain is the most debilitating symptom of migraine. The cause of migraine pain likely requires activation of meningeal nociceptors. Mast cell degranulation, with subsequent meningeal nociceptor activation, has ... -
Spinal Inhibition of P2XR or p38 Signaling Disrupts Hyperalgesic Priming in Male, but not Female, Mice
Recent studies have demonstrated sexual dimorphisms in the mechanisms contributing to the development of chronic pain. Here we tested the hypothesis that microglia might preferentially regulate hyperalgesic priming in male ... -
The Antidiabetic Drug Metformin Prevents and Reverses Neuropathic Pain and Spinal Cord Microglial Activation in Male but not Female Mice
(Academic Press Ltd- Elsevier Science Ltd, 2018-11-01)Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK ... -
Transcriptome Analysis of the Human Tibial Nerve Identifies Sexually Dimorphic Expression of Genes Involved in Pain, Inflammation, and Neuro-Immunity
Sex differences in gene expression are important contributors to normal physiology and mechanisms of disease. This is increasingly apparent in understanding and potentially treating chronic pain where molecular mechanisms ...