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dc.contributor.authorJoos, Kathleenen_US
dc.contributor.authorDe Ridder, Dirken_US
dc.contributor.authorBoey, Ronny A.en_US
dc.contributor.authorVanneste, Svenen_US
dc.date.accessioned2014-11-20T22:13:21Z
dc.date.available2014-11-20T22:13:21Z
dc.date.created2014-10-13
dc.identifier.issn1662-5161en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4212
dc.description.abstractIntroduction: Stuttering is defined as speech characterized by verbal dysfluencies, but should not be seen as an isolated speech disorder, but as a generalized sensorimotor timing deficit due to impaired communication between speech related brain areas. Therefore we focused on resting state brain activity and functional connectivity.; Method: We included 11 patients with developmental stuttering and 11 age matched controls. To objectify stuttering severity and the impact on quality of life (QoL), we used the Dutch validated Test for Stuttering Severity-Readers (TSS-R) and the Overall Assessment of the Speaker's Experience of Stuttering (OASES), respectively. Furthermore, we used standardized low resolution brain electromagnetic tomography (sLORETA) analyses to look at resting state activity and functional connectivity differences and their correlations with the TSS-R and OASES.; Results: No significant results could be obtained when looking at neural activity, however significant alterations in resting state functional connectivity could be demonstrated between persons who stutter (PWS) and fluently speaking controls, predominantly interhemispheric, i.e., a decreased functional connectivity for high frequency oscillations (beta and gamma) between motor speech areas (BA44 and 45) and the contralateral premotor (BA6) and motor (BA4) areas. Moreover, a positive correlation was found between functional connectivity at low frequency oscillations (theta and alpha) and stuttering severity, while a mixed increased and decreased functional connectivity at low and high frequency oscillations correlated with QoL.; Discussion: PWS are characterized by decreased high frequency interhemispheric functional connectivity between motor speech, premotor and motor areas in the resting state, while higher functional connectivity in the low frequency bands indicates more severe speech disturbances, suggesting that increased interhemispheric and right sided functional connectivity is maladaptive.;en_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.urihttp://dx.doi.org/10.3389/fnhum.2014.00783en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2014 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectStutteringen_US
dc.subjectFunctional connectivityen_US
dc.subjectBrainen_US
dc.subjectSpeechen_US
dc.subjectQuality of lifeen_US
dc.subjectTest for Stuttering Severity-Readers (TSS-R)en_US
dc.subjectOverall Assessment of the Speaker’s Experience of Stuttering (OASES)en_US
dc.titleFunctional Connectivity Changes in Adults with Developmental Stuttering: A Preliminary Study using Quantitative Electro-Encephalographyen_US
dc.typeTexten_US
dc.type.genrearticleen_US
dc.identifier.bibliographicCitationJoos, Kathleen, Dirk De Ridder, Ronny A. Boey, and Sven Vanneste. 2014. "Functional connectivity changes in adults with developmental stuttering: a preliminary study using quantitative electro-encephalography." Frontiers In Human Neuroscience 8(783).en_US
dc.source.journalFrontiers in Human Neuroscienceen_US
dc.identifier.volume8en_US
dc.contributor.ORCID0000-0002-9906-1836 (Vanneste, S)en_US


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