Palmer, Kelli L.
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Kelli Palmer is an Assistant Professor in the Department of Molecular and Cell Biology. Dr. Palmer uses genomic, transcriptomic, and biochemical approaches to study antibiotic resistance in pathogenic bacteria. Her research focuses on microorganisms contributing to significant mortality and cost burdens in the health care industry.
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Works in Treasures @ UT Dallas are made available exclusively for educational purposes such as research or instruction. Literary rights, including copyright for published works held by the creator(s) or their heirs, or other third parties may apply. All rights are reserved unless otherwise indicated by the copyright owner(s).
Recent Submissions
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A Type I Restriction-Modification System Associated with Enterococcus Faecium Subspecies Separation
(Amer Soc Microbiology, 2019-01-09)The gastrointestinal colonizer Enterococcus faecium is a leading cause of hospital-acquired infections. Multidrug-resistant (MDR) E. faecium isolates are particularly concerning for infection treatment. Previous comparative ... -
Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci
(American Society for Microbiology, 2019-05-21)Enterococcus faecalis is a human intestinal pathobiont with intrinsic and acquired resistance to many antibiotics, including vancomycin. Nature provides a diverse and virtually untapped repertoire of bacterial viruses, or ... -
Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection
Urinary tract infections (UTIs) are the most commonly reported infections in adult women and have high rates of recurrence, especially in postmenopausal women. Recurrent UTI (RUTI) greatly reduces quality of life, places ... -
Multifaceted Roles of Environmental Factors toward Dental Implant Performance: Observations from Clinical Retrievals and In Vitro Testing
Objective: Oral bacteria and periodontal pathogen have been predominantly linked with early- and late- stage failures of titanium (Ti) dental implants (DI) respectively. This study is based on the hypothesis that bacterial ... -
EfrEF and the Transcription Regulator ChIR Are Required for Chlorhexidine Stress Response in Enterococcus faecalis V583
Enterococcus faecalis is an opportunistic pathogen and leading cause of health care-associated infections. Daily chlorhexidine gluconate (CHG) bathing of patients is generally regarded as an effective strategy to reduce ... -
An Attenuated CRISPR-Cas System In Enterococcus faecalis Permits DNA Acquisition
Antibiotic-resistant bacteria are critical public health concerns. Among the prime causative factors for the spread of antibiotic resistance is horizontal gene transfer (HGT). A useful model organism for investigating the ... -
Reduced Chlorhexidine and Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus Faecium after Serial Chlorhexidine Exposure
(Amer Soc Microbiology, 2018-10-22)Vancomycin-resistant Enterococcus faecium strains (VREfm) are critical public health concerns because they are among the leading causes of hospital-acquired bloodstream infections. Chlorhexidine (CHX) is a bisbiguanide ... -
Modulators of Enterococcus Faecalis Cell Envelope Integrity and Antimicrobial Resistance Influence Stable Colonization of the Mammalian Gastrointestinal Tract
(Amer Soc Microbiology, 2018-10-22)The Gram-positive bacterium Enterococcus faecalis is both a colonizer of the gastrointestinal tract (GIT) and an agent of serious nosocomial infections. Although it is typically required for pathogenesis, GIT colonization ... -
Exploiting CRISPR-Cas to Manipulate Enterococcus Faecalis Populations
(eLife Sciences Publications Ltd, 2018-08-20)CRISPR-Cas provides a barrier to horizontal gene transfer in prokaryotes. It was previously observed that functional CRISPR-Cas systems are absent from multidrug-resistant (MDR) Enterococcus faecalis, which only possess ... -
Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria
(Amer Soc Microbiology, 2018-06-01)Synthesis and integrity of the cytoplasmic membrane are fundamental to cellular life. Experimental evolution studies have hinted at unique physiology in the Gram-positive bacteria Streptococcus mitis and S. oralis. These ... -
Evaluation of Mammalian and Bacterial Cell Activity on Titanium Surface Coated with Dicationic Imidazolium-Based Ionic Liquids
(Royal Soc Chemistry, 2016-04-04)This work presents a new strategy to protect titanium surfaces against bacterial colonization and biofilm formation using dicationic imidazolium-based ionic liquid coatings. Ionic liquids (ILs) were designed as multi-functional ... -
Chlorhexidine Induces Vana-Type Vancomycin Resistance Genes in Enterococci
(American Society for Microbiology, 2016-03/25)Chlorhexidine is a bisbiguanide antiseptic used for infection control. Vancomycin-resistant E. faecium (VREfm) is among the leading causes of hospital-acquired infections. VREfm may be exposed to chlorhexidine at supra- ... -
Mutations Associated with Reduced Surotomycin Susceptibility in Clostridium Difficile and Enterococcus Species
(American Society for Microbiology, 2015-05-04)Clostridium difficile infection (CDI) is an urgent public health concern causing considerable clinical and economic burdens. CDI can be treated with antibiotics, but recurrence of the disease following successful treatment ... -
Comparative Analysis of the Orphan Crispr2 Locus in 242 Enterococcus Faecalis Strains
(Public Library of Science, 2015-09-23)Clustered, Regularly Interspaced Short Palindromic Repeats and their associated Cas proteins (CRISPR-Cas) provide prokaryotes with a mechanism for defense against mobile genetic elements (MGEs). A CRISPR locus is a molecular ... -
Dicationic Imidazolium-Based Ionic Liquids: A New Strategy for Non-Toxic and Antimicrobial Materials
New dicationic imidazolium-based ionic liquids (ILs) were synthesized, characterized and tested in regards to cytotoxicity and antimicrobial activity. Insertion of a new cationic head and use of organic anions increased ...
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