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dc.contributor.authorRainbolt, Elizabeth A.en_US
dc.contributor.authorMiller, J. B.en_US
dc.contributor.authorWashington, Katherine E.en_US
dc.contributor.authorSenevirathne, Suchithra A.en_US
dc.contributor.authorBiewer, Michael C.en_US
dc.contributor.authorSiegwart, D. J.en_US
dc.contributor.authorStefan, Mihaela C.en_US
dc.date.accessioned2015-03-27T22:16:27Z
dc.date.available2015-03-27T22:16:27Z
dc.date.created2015-01-16en_US
dc.date.issued2015-01-16en_US
dc.identifier.issn2050-7518en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4389
dc.descriptionSupplementary information included.en_US
dc.description.abstractBlock copolymers synthesized by the ring-opening polymerization of γ-2-[2-(2-methoxyethoxy)ethoxy]ethoxy-ε-caprolactone (ME₃CL), γ-2-methoxyethoxy-ε-caprolactone (ME₁CL), and ε-caprolactone (CL) are reported. Previously, diblock copolymers of PME₃CL-b-PME₁CL displayed excellent thermoresponsive tunability (31-43 ⁰C) and self-assembled into micelles with moderate thermodynamic stability. In this report, two strategies are employed to enhance thermodynamic stability of PME₃CL/PME₁CL-type block copolymer micelles while maintaining their attractive thermoresponsive qualities: modification of the end group position and alteration of hydrophobic block composition by using both ME₁CL and CL. These new thermoresponsive amphiphilic block copolymers showed lower critical micelle concentration (CMC) values by one order of magnitude and formed thermodynamically stable micelles. Furthermore they demonstrated good biocompatibility and up to 4.97 wt% doxorubicin loading, more than double the amount loaded into the PME₃CL-type polymeric micelles previously reported.en_US
dc.description.sponsorship"M.C.S. gratefully acknowledges financial support from the Welch Foundation (AT1740), and National Science Foundation (DMR-0956116 & CHE-1126177). D.J.S. gratefully acknowledges financial support from the Welch Foundation (I-1855) and CPRIT (R1212 and RP140110)."en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.urihttp://dx.doi.org/10.1039/c4tb02016b
dc.rights©2015 The Royal Society of Chemistry. This article may not be further made available or distributed.en_US
dc.sourceJournal of Materials Chemistry B
dc.subjectPolymers--Biocompatibilityen_US
dc.subjectCritical micelle concentrationen_US
dc.subjectBlock copolymersen_US
dc.subjectThermodynamic equilibriumen_US
dc.subjectRing-opening polymerizationen_US
dc.titleFine-tuning Thermoresponsive Functional Poly(ε-caprolactone)s to Enhance Micelle Stability and Drug Loadingen_US
dc.typeTexten_US
dc.type.genreArticleen_US
dc.identifier.bibliographicCitationRainbolt, E. A., J. B. Miller, K. E. Washington, S. A. Senevirathne, et al. 2015. "Fine-tuning thermoresponsive functional poly(ε-caprolactone)s to enhance micelle stability and drug loading." Journal of Materials Chemistry B 3(9): 1779-1787.en_US
dc.identifier.volume3en_US
dc.identifier.issue9en_US
dc.contributor.utdAuthorBiewer, Michael C.en_US
dc.contributor.utdAuthorStefan, Mihaela C.en_US
dc.contributor.VIAF55039821 (Stefan, MC)


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