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dc.contributor.authorChoi, Rachelen_US
dc.contributor.authorMeyers, Ericen_US
dc.contributor.authorGanzer, Patricken_US
dc.contributor.authorHays, Sethen_US
dc.contributor.authorKilgard, Michael P.en_US
dc.contributor.authorRennaker, Robert L.en_US
dc.descriptionA thesis written by Rachel Choi, an undergraduate neuroscience major in the School of Behavioral and Brain Sciences, in partial completion of the Collegium V Honors Program.en_US
dc.description.abstractIschemic stroke and spinal cord injury are neurological injuries that produce persisting motor deficits. Additionally, the majority of those suffering from impairments due to ischemic stroke or spinal cord injury rarely fully recover complete function with current treatment options. Here, we investigate the use of vagus nerve stimulation (VNS), which facilitates specific and long-lasting plasticity after injury. Sprague-Dawley rats affected by a spinal cord contusion at C5 and administered VNS paired with rehabilitation exhibited significant recovery of forelimb strength on an isometric pull task. We also propose similar recovery of supination function in Sprague-Dawley rats affected by endothelin-1‐induced focal motor cortex ischemic stroke. Thus, VNS paired with rehabilitation may be an effective therapeutic tool in the event of neurological injury such as ischemic stroke or spinal cord injury.en_US
dc.rightsCC-BY 4.0 (Attribution)en_US
dc.rights©2015 The Authorsen_US
dc.subjectVagus Nerve Stimulationen_US
dc.subjectRats, Sprague-Dawleyen_US
dc.subjectSpinal Cord Injuriesen_US
dc.titleVagus Nerve Stimulation and Rehabilitation Improves Recovery of a Motor Task after Neurological Injuryen_US
dc.identifier.bibliographicCitationChoi, R., E. Meyers, P. Ganzer, S. Hays, M.P. Kilgard and R.L. Rennaker (2015). Vagus Nerve stimulation and rehabilitation improves recovery of a motor task after neurological injury (Honors thesis). Retrieved from
dc.contributor.ISNI0000 0001 3852 473X (Kilgard, MP)en_US
dc.contributor.ISNI0000 0001 2879 2132 (Rennaker, RL)en_US

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CC-BY 4.0 (Attribution)
Except where otherwise noted, this item's license is described as CC-BY 4.0 (Attribution)