Show simple item record

dc.contributor.authorFestini, Sara B.en_US
dc.contributor.authorBernard, Jessica A.en_US
dc.contributor.authorKwak, Youngbinen_US
dc.contributor.authorPeltier, Scotten_US
dc.contributor.authorBohnen, Nicolaas I.en_US
dc.contributor.authorMüller, Martijn,L.T.M.en_US
dc.contributor.authorDayalu, Praveenen_US
dc.contributor.authorSeidler, Rachael D.en_US
dc.date.accessioned2015-07-20T19:47:51Z
dc.date.available2015-07-20T19:47:51Z
dc.date.created2015-04-21
dc.date.issued2015-04-21en_US
dc.identifier.issn1662-5161en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4580
dc.descriptionIncludes supplementary data.en_US
dc.descriptionArticle in other file formats available at Frontiers in Human Neuroscience website.en_US
dc.description.abstractAlthough nigrostriatal changes are most commonly affiliated with Parkinson's disease, the role of the cerebellum in Parkinson's has become increasingly apparent. The present study used lobule-based cerebellar resting state functional connectivity to (1) compare cerebellar-whole brain and cerebellar-cerebellar connectivity in Parkinson's patients both ON and OFF L-DOPA medication and controls, and to (2) relate variations in cerebellar connectivity to behavioral performance. Results indicated that, when contrasted to the control group, Parkinson's patients OFF medication had increased levels of cerebellar-whole brain and cerebellar-cerebellar connectivity, whereas Parkinson's patients ON medication had decreased levels of cerebellar-whole brain and cerebellar-cerebellar connectivity. Moreover, analyses relating levels of cerebellar connectivity to behavioral measures demonstrated that, within each group, increased levels of connectivity were most often associated with improved cognitive and motor performance, but there were several instances where increased connectivity was related to poorer performance. Overall, the present study found medication-variant cerebellar connectivity in Parkinson's patients, further demonstrating cerebellar changes associated with Parkinson's disease and the moderating effects of medication.;en_US
dc.description.sponsorshipen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.urihttp://dx.doi.org/10.3389/fnhum.2015.00214en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2015 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectLevodopaen_US
dc.subjectParkinson Diseaseen_US
dc.subjectCerebellumen_US
dc.subjectLobulesen_US
dc.titleAltered Cerebellar Connectivity in Parkinson's Patients ON and OFF L-DOPA Medicationen_US
dc.type.genrearticleen_US
dc.identifier.bibliographicCitationFestini, Sara B., Jessica A. Bernard, Youngbin Kwak, Scott Peltier, et al. 2015. "Altered cerebellar connectivity in Parkinson's patients ON and OFF L-DOPA medication." Frontiers In Human Neuroscience 9(214): doi:10.3389/fnhum.2015.00214.en_US
dc.source.journalFrontiers in Human Neuroscienceen_US
dc.identifier.volume9en_US
dc.identifier.issue214en_US


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0 (Attribution)
Except where otherwise noted, this item's license is described as CC BY 4.0 (Attribution)