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Biochemical Studies of Regulatory Heme-Protein Interaction and Heme Regulation in Yeast
Heme is a small biomolecule produced and used by living organisms from bacteria to humans. Heme consists of an organic porphyrin ring that coordinates an iron ion, Fe(II) or Fe(III), in its center. Heme can be in an ...
Molecular Mechanisms Underlying Aerobic Respiration and Heme Regulation in Yeast
Heme is an important signaling molecule with diverse functions in living organisms ranging from regulating gene transcription to circadian rhythm. In yeast, heme serves as a secondary messenger of oxygen, as heme synthesis ...
Mitochondrial Respiration Promotes Non-Small Cell Lung Cancer Cell Proliferation and Function
Lung cancer is the leading cause of cancer related death both in the USA and worldwide. More than 80% of the lung cancer cases are non-small cell lung cancer (NSCLC). Since Otto Warburg made the first observation that the ...
Increased Heme Flux and Mitochondrial Resporation Enhance Tumorigenic Functions in Non-Small Cell Lung Cancer Cells
Lung cancer is the leading cause of cancer related deaths in United States, and about 85% of the cases are Non-small cell lung cancer (NSCLC). Many targeted therapies have been developed to treat lung cancer. Unfortunately, ...
Targeting Heme Function and Mitochondrial Respiration in Non-Small Cell Lung Cancer
Each year lung cancer causes more morbidities than cancers of colon, breast, and prostate combined. The American Cancer Society estimates that lung cancer will claim about 150,000 lives in 2018. Conventional and targeted ...
Dissecting the Role of Heme in Regulating Yeast and Mammalian KDM4 Histone Demethylases
Heme (Iron protoporphyrin IX) is an essential biological molecule and an important metallonutrient for organisms ranging from bacteria to humans. It is also a signaling molecule that modulates the activities of diverse ...