Dr. Heng Du is an Assistant Professor in the Biological Sciences department. His research focuses on the mitochondrial role in neurodegenerative diseases. There are two themes to this focus: 1)explores the synaptic mitochondria-associated mechanisms of neurodegeneration in neurological diseases. 2)is translational study on mitochondrial medicine to protect neurodegeneration under pathological states, by using a combination of molecular biology, cell biology, electrophysiology and pathology on research models including gene-modified animal, cell models and embryonic and induced pluripotent stem cells.

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Recent Submissions

  • Niclosamide Ethanolamine Improves Diabetes and Diabetic Kidney Disease in Mice 

    Han, Pengxun; Shao, Mumin; Guo, Lan; Wang, Wenjing; Song, Gaofeng; Yu, Xuewen; Zhang, Chunlei; Ge, Na; Yi, Tiegang; Li, Shunmin; Du, Heng; Sun, Huili
    Diabetes and its renal complications are major medical challenges worldwide. There are no effective drugs currently available for treating diabetes and diabetic kidney disease (DKD), especially in type 1 diabetes (T1D). ...
  • Deregulation of Mitochondrial F1FO-ATP Synthase via OSCP in Alzheimer's Disease 

    Beck, Simon J.; Guo, Lan; Phensy, Aarron; Tian, Jing; Wang, Lu; Tandon, Neha; Gauba, Esha; Lu, Lin; Pascual, J. M.; Kroener, Sven; Du, Heng
    F1FO-ATP synthase is critical for mitochondrial functions. The deregulation of this enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and activated mitochondrial permeability transition (mPT), ...
  • Synaptosomal Mitochondrial Dysfunction In 5xFAD Mouse Model of Alzheimer's Disease 

    Wang, Lu; Guo, Lan; Lu, Lin; Sun, Huili; Shao, Muming; Beck, Simon J.; Li, Lin; Ramachandran, Janani; Du, Yifeng; Du, Heng (2018-06-01)
    Brain mitochondrial dysfunction is hallmark pathology of Alzheimer’s disease (AD). Recently, the role of synaptosomal mitochondrial dysfunction in the development of synaptic injury in AD has received increasing attention. ...
  • Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice 

    Lu, Lin; Guo, Lan; Gauba, Esha; Tian, Jing; Wang, Lu; Tandon, Neha; Shankar, Malini; Beck, Simon J.; Du, Yifeng; Du, Heng (Public Library of Science, 2015-12-03)
    Alzheimer's disease (AD) is heterogeneous and multifactorial neurological disorder; and the risk factors of AD still remain elusive. Recent studies have highlighted the role of vascular factors in promoting the progression ...