Du, Heng
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Dr. Heng Du is an Assistant Professor in the Biological Sciences department. His research focuses on the mitochondrial role in neurodegenerative diseases. There are two themes to this focus: 1)explores the synaptic mitochondria-associated mechanisms of neurodegeneration in neurological diseases. 2)is translational study on mitochondrial medicine to protect neurodegeneration under pathological states, by using a combination of molecular biology, cell biology, electrophysiology and pathology on research models including gene-modified animal, cell models and embryonic and induced pluripotent stem cells.
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Recent Submissions
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Cyclophilin D Deficiency Protects Against the Development of Mitochondrial ROS and Cellular Inflammation in Aorta
(Academic Press Inc Elsevier Science, 2018-12-13)Introduction: Inflammation and oxidative stress are closely correlated in the pathology of cardiovascular disease. Mitochondrial cyclophilin D (CypD), the important modulator for mPTP opening, is increasingly recognized ... -
Cyclophilin D Deficiency Attenuates Mitochondrial F1Fo ATP Synthase Dysfunction Via OSCP In Alzheimer's Disease
(Academic Press Inc Elsevier Science, 2018-09-26)Mitochondrial dysfunction is pivotal in inducing synaptic injury and neuronal stress in Alzheimer's disease (AD). Mitochondrial F1Fo ATP synthase deregulation is a hallmark mitochondrial defect leading to oxidative ... -
Amyloid Beta-Mediated KIF5A Deficiency Disrupts Anterograde Axonal Mitochondrial Movement
Mitochondria are crucial organelles for neurophysiology and brain mitochondrial defects constitute a characteristic of Alzheimer's disease (AD). Impaired axonal mitochondrial traffic, especially the anterograde axonal ... -
Niclosamide Ethanolamine Improves Diabetes and Diabetic Kidney Disease in Mice
Diabetes and its renal complications are major medical challenges worldwide. There are no effective drugs currently available for treating diabetes and diabetic kidney disease (DKD), especially in type 1 diabetes (T1D). ... -
Deregulation of Mitochondrial F1FO-ATP Synthase via OSCP in Alzheimer's Disease
F1FO-ATP synthase is critical for mitochondrial functions. The deregulation of this enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and activated mitochondrial permeability transition (mPT), ... -
Synaptosomal Mitochondrial Dysfunction In 5xFAD Mouse Model of Alzheimer's Disease
(2018-06-01)Brain mitochondrial dysfunction is hallmark pathology of Alzheimer’s disease (AD). Recently, the role of synaptosomal mitochondrial dysfunction in the development of synaptic injury in AD has received increasing attention. ... -
Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice
(Public Library of Science, 2015-12-03)Alzheimer's disease (AD) is heterogeneous and multifactorial neurological disorder; and the risk factors of AD still remain elusive. Recent studies have highlighted the role of vascular factors in promoting the progression ...
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