Sheena D'Arcy joined the UTD Chemistry faculty in 2015. Her research interests include:
- Chromatin dynamics
- Cell-specific gene expression
- X-ray crystallography
- Structural biology
- hydrogen-deuterium exchange
- mass spectroscopy
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Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding (Amer Chemical Soc, 2018-12-06)Nucleosome assembly proteins (Naps) influence chromatin dynamics by directly binding to histones. Here we provide a comprehensive structural and biochemical analysis of a Nap protein from Caenorhabditis elegans (CeNap1). ...
We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of ...
Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible Gal Locus (Amer Soc Microbiology, 2016-02-16)Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture. Here, we use the GAL locus in Saccharomyces cerevisiae to investigate the influence of Nap1 ...