Now showing items 1-2 of 2

    • Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible Gal Locus 

      Chen, Xu; D'Arcy, Sheena; Radebaugh, Catherine A.; Krzizike, Daniel D.; Giebler, Holli A.; Huang, Liangquan; Nyborg, Jennifer K.; Luger, Karolin; Stargell, Laurie A. (Amer Soc Microbiology, 2016-02-16)
      Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture. Here, we use the GAL locus in Saccharomyces cerevisiae to investigate the influence of Nap1 ...
    • Importin-9 Wraps Around the H2A-H2B Core to Act as Nuclear Importer and Histone Chaperone 

      Padavannil, A.; Sarkar, Prithwijit; Kim, S. J.; Cagatay, T.; Jiou, J.; Brautigam, C. A.; Tomchick, D. R.; Sali, A.; D'Arcy, Sheena; Chook, Y. M.
      We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of ...