Juhn-whan Kim is an Assistant Professor of Molecular and Cell Biology in the Biological Sciences department. He also is the head of the Jay Kim Lab. His research focuses on "understanding the role of hypoxic response in the regulation of tumor microenvironmental remodeling and metabolic reprograming in cancers." He is also seeking to understand "the role of stromal cells including fibroblasts, adipocytes and inflammatory cells in cancer progression." His current interests include:
- Stromal fibroblasts within the tumor microenvironment
- Adipocyte hypoxic response in mammary tumor progression
- Role of HIFs in non-small cell lung cancers
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Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype (Frontiers Media S.A., 2019-05-07)Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate ...
Spatial Angular Compounding Technique for H-Scan Ultrasound Imaging. (2018-10-22)H-Scan is a new ultrasound imaging technique that relies on matching a model of pulse-echo formation to the mathematics of a class of Gaussian-weighted Hermite polynomials. This technique may be beneficial in the measurement ...
A New Perspective on the Heterogeneity of Cancer Glycolysis (2018-10-22)Tumors are dynamic metabolic systems which highly augmented metabolic fluxes and nutrient needs to support cellular proliferation and physiological function. For many years, a central hallmark of tumor metabolism has ...
Regulation of Acetate Utilization by Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC) (Cognizant Communication Corporation, 2018-10-22)Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal [¹⁸F]fluorodeoxyglucose (FDG) and [¹¹C]acetate uptake, as revealed by positron emission tomography/computed ...
The Distinct Metabolic Phenotype of Lung Squamous Cell Carcinoma Defines Selective Vulnerability to Glycolytic Inhibition (Springer Nature, 2018-08-20)Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. However, metabolic ...
A Measurement of the Calorimeter Response to Single Hadrons and Determination of the Jet Energy Scale Uncertainty Using LHC Run-1 PP-Collision Data with the ATLAS Detector (Nature Publishing Group, 2016-05-18)In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a ...