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dc.contributor.authorFiore, Vincenzo G.en_US
dc.contributor.authorRigoli, Francescoen_US
dc.contributor.authorStenner, Max-Philippen_US
dc.contributor.authorZaehle, Tinoen_US
dc.contributor.authorHirth, Franken_US
dc.contributor.authorHeinze, Hans-Jochenen_US
dc.contributor.authorDolan, Raymond J.en_US
dc.descriptionIncludes supplementary material.en_US
dc.description.abstractAction selection in the basal ganglia is often described within the framework of a standard model, associating low dopaminergic drive with motor suppression. Whilst powerful, this model does not explain several clinical and experimental data, including varying therapeutic efficacy across movement disorders. We tested the predictions of this model in patients with Parkinson’s disease, on and off subthalamic deep brain stimulation (DBS), focussing on adaptive sensory-motor responses to a changing environment and maintenance of an action until it is no longer suitable. Surprisingly, we observed prolonged perseverance under on-stimulation, and high inter-individual variability in terms of the motor selections performed when comparing the two conditions. To account for these data, we revised the standard model exploring its space of parameters and associated motor functions and found that, depending on effective connectivity between external and internal parts of the globus pallidus and saliency of the sensory input, a low dopaminergic drive can result in increased, dysfunctional, motor switching, besides motor suppression. This new framework provides insight into the biophysical mechanisms underlying DBS, allowing a description in terms of alteration of the signal-to-baseline ratio in the indirect pathway, which better account of known electrophysiological data in comparison with the standard model.en_US
dc.description.sponsorshipWellcome Trust (091593/Z/10/Z, 098362/Z/12/Z); DFG (SFB 779, He 1531/11-1, STE 2091/1-2); MRC (MR/L010666/1)en_US
dc.publisherNature Publicationsen_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2016 The Authors. All Rights Reserved.en_US
dc.subjectBasal Gangliaen_US
dc.subjectParkinson Diseaseen_US
dc.subjectDopaminergic mechanismsen_US
dc.subjectDeep Brain Stimulationen_US
dc.subjectMovement disordersen_US
dc.subjectGlobus pallidusen_US
dc.titleChanging Pattern In The Basal Ganglia: Motor Switching Under Reduced Dopaminergic Driveen_US
dc.identifier.bibliographicCitationFiore, Vincenzo G., Francesco Rigoli, Max-Philipp Stenner, Tino Zaehle, et al. 2016. "Changing pattern in the basal ganglia: Motor switching under reduced dopaminergic drive." Scientific Reports 6, doi: 10.1038/srep23327en_US
dc.source.journalScientific Reportsen_US
dc.contributor.utdAuthorFiore, Vincenzo G.en_US

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