Sirsi, Shashank R.
Shashank Sirsi is an Assistant Professor of Bioengineering. He joined the Erik Jonsson School faculty "to build a state-of-the-art image-guided drug delivery program for cancer therapy." Dr. Sirsi serves as head of the Image-Guided Drug Delivery Lab where his research interests include:
- Image-guided drug delivery, and
- Ultrasound imaging
Works in Treasures @ UT Dallas are made available exclusively for educational purposes such as research or instruction. Literary rights, including copyright for published works held by the creator(s) or their heirs, or other third parties may apply. All rights are reserved unless otherwise indicated by the copyright owner(s).
(Acoustical Society of America, 2019-06-14)A phase-change contrast agent (PCCA) can be activated from a liquid (nanodroplet) state using pulsed ultrasound (US) energy to form a larger highly echogenic microbubble (MB). PCCA activation is dependent on the ambient ...
Hyposialylated IgG Activates Endothelial IgG Receptor FcγRIIB to Promote Obesity-Induced Insulin Resistance (American Society for Clinical Investigation, 2018-11-05)Type 2 diabetes mellitus (T2DM) is a common complication of obesity. Here, we have shown that activation of the IgG receptor FcγRIIB in endothelium by hyposialylated IgG plays an important role in obesity-induced insulin ...
Novel Method for the Formation of Monodisperse Superheated Perfluorocarbon Nanodroplets as Activatable Ultrasound Contrast Agents (Royal Society of Chemistry, 2018-08-20)Microbubble (MB) contrast agents have positively impacted the clinical ultrasound (US) community worldwide. Their use in molecular US imaging applications has been hindered by their limited distribution to the vascular ...