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Novel Method for the Formation of Monodisperse Superheated Perfluorocarbon Nanodroplets as Activatable Ultrasound Contrast Agents

De, Gracia Lux; Vezeridis, A. M.; Lux, J.; Armstrong, A. M.; Sirsi, Shashank R.; Hoyt, Kenneth; Mattrey, R. F. (Royal Society of Chemistry, 2018-08-20)

Microbubble (MB) contrast agents have positively impacted the clinical ultrasound (US) community worldwide. Their use in molecular US imaging applications has been hindered by their limited distribution to the vascular ...

Hyposialylated IgG Activates Endothelial IgG Receptor FcγRIIB to Promote Obesity-Induced Insulin Resistance

Tanigaki, K.; Sacharidou, A.; Peng, J.; Chambliss, K. L.; Yuhanna, I. S.; Ghosh, Debabrata; Ahmed, M.; Szalai, A. J.; Vongpatanasin, W.; Mattrey, R. F.; Chen, Q.; Azadi, P.; Lingvay, I.; Botto, M.; Holland, W. L.; Kohler, J. J.; Sirsi, Shashank R.; Hoyt, Kenneth; Shaul, P. W.; Mineo, C. (American Society for Clinical Investigation, 2018-11-05)

Type 2 diabetes mellitus (T2DM) is a common complication of obesity. Here, we have shown that activation of the IgG receptor FcγRIIB in endothelium by hyposialylated IgG plays an important role in obesity-induced insulin ...