Now showing items 1-5 of 5

    • Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models 

      Avona, Amanda; Burgos-Vega, Carolina; Burton, Michael D.; Akopian, A. N.; Price, Theodore J.; Dussor, Gregory (Society for Neuroscience, 2019-05-29)
      Migraine is the second leading cause for disability worldwide and the most common neurological disorder. It is also three times more common in women; reasons for this sex difference are not known. Using preclinical behavioral ...
    • Non-Invasive Dural Stimulation in Mice: A Novel Preclinical Model of Migraine 

      Burgos-Vega, Carolina Christina; Quigley, Lilyana D.; dos Santos, Gabriela Trevisan; Yan, Flora; Asiedu, Marina; Jacobs, Blaine; Motina, Marina; Safdar, Nida; Yousuf, Hayyan; Avona, Amanda; Price, Theodore J.; Dussor, Greg (Sage Publications Ltd, 2018-05-31)
      Background Migraine is characterized by a collection of neurological symptoms in the absence of injury or damage. However, several common preclinical migraine models require significant damage to the skull to stimulate the ...
    • Protease Activated Receptor 2 (PAR2) Activation Causes Migraine-Like Pain Behaviors in Mice 

      Hassler, Shayne N.; Ahmad, Fatima B.; Burgos-Vega, Carolina C.; Boitano, Scott; Vagner, Josef; Price, Theodore J.; Dussor, Gregory (Sage Publications Ltd, 2018-05-31)
      Background Pain is the most debilitating symptom of migraine. The cause of migraine pain likely requires activation of meningeal nociceptors. Mast cell degranulation, with subsequent meningeal nociceptor activation, has ...
    • Sex Differences in the Expression of Calcitonin Gene-Related Peptide Receptor Components in the Spinal Trigeminal Nucleus 

      Ji, Y.; Rizk, A.; Voulalas, P.; Aljohani, H.; Akerman, S.; Dussor, Gregory; Keller, A.; Masri, R. (Elsevier B.V., 2019-04-24)
      Background and purpose: Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology. CGRP acts primarily by activating a receptor composed of 3 proteins: calcitonin receptor-like receptor ...
    • Targeted Acid-Sensing Ion Channel Therapies for Migraine 

      Karsan, Nazia; Gonzales, Eric B.; Dussor, Gregory
      Acid-sensing ion channels (ASICs) are a family of ion channels, consisting of four members; ASIC1 to 4. These channels are sensitive to changes in pH and are expressed throughout the central and peripheral nervous ...