Now showing items 1-3 of 3
Activation of the Integrated Stress Response in Nociceptors Drives Methylglyoxal-Induced Pain
(Lippincott Williams & Wilkins, 2019-01)
Methylglyoxal (MGO) is a reactive glycolytic metabolite associated with painful diabetic neuropathy at plasma concentrations between 500 nM and 5 μM. The mechanisms through which MGO causes neuropathic pain at these ...
Emerging Neurotechnology for Antinoceptive Mechanisms and Therapeutics Discovery
(Elsevier Advanced Technology, 2018-11-13)
The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to ...
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain
(Soc Neuroscience, 2019-01-16)
Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including ...