Now showing items 1-4 of 4
Sex Differences in the Expression of Calcitonin Gene-Related Peptide Receptor Components in the Spinal Trigeminal Nucleus
(Elsevier B.V., 2019-04-24)
Background and purpose: Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology. CGRP acts primarily by activating a receptor composed of 3 proteins: calcitonin receptor-like receptor ...
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models
(Society for Neuroscience, 2019-05-29)
Migraine is the second leading cause for disability worldwide and the most common neurological disorder. It is also three times more common in women; reasons for this sex difference are not known. Using preclinical behavioral ...
Activation of the Integrated Stress Response in Nociceptors Drives Methylglyoxal-Induced Pain
(Lippincott Williams & Wilkins, 2019-01)
Methylglyoxal (MGO) is a reactive glycolytic metabolite associated with painful diabetic neuropathy at plasma concentrations between 500 nM and 5 μM. The mechanisms through which MGO causes neuropathic pain at these ...
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain
(Soc Neuroscience, 2019-01-16)
Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including ...