Now showing items 1-3 of 3
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models
(Society for Neuroscience, 2019-05-29)
Migraine is the second leading cause for disability worldwide and the most common neurological disorder. It is also three times more common in women; reasons for this sex difference are not known. Using preclinical behavioral ...
Non-Invasive Dural Stimulation in Mice: A Novel Preclinical Model of Migraine
(Sage Publications Ltd, 2018-05-31)
Background Migraine is characterized by a collection of neurological symptoms in the absence of injury or damage. However, several common preclinical migraine models require significant damage to the skull to stimulate the ...
The Antidiabetic Drug Metformin Prevents and Reverses Neuropathic Pain and Spinal Cord Microglial Activation in Male but not Female Mice
(Academic Press Ltd- Elsevier Science Ltd, 2018-11-01)
Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK ...