Now showing items 1-3 of 3
Protease Activated Receptor 2 (PAR2) Activation Causes Migraine-Like Pain Behaviors in Mice
(Sage Publications Ltd, 2018-05-31)
Background Pain is the most debilitating symptom of migraine. The cause of migraine pain likely requires activation of meningeal nociceptors. Mast cell degranulation, with subsequent meningeal nociceptor activation, has ...
The Antidiabetic Drug Metformin Prevents and Reverses Neuropathic Pain and Spinal Cord Microglial Activation in Male but not Female Mice
(Academic Press Ltd- Elsevier Science Ltd, 2018-11-01)
Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK ...
Emerging Neurotechnology for Antinoceptive Mechanisms and Therapeutics Discovery
(Elsevier Advanced Technology, 2018-11-13)
The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to ...