Campbell, Zachary T.

 

Zachary Campbell joined the UTD faculty in 2015 as an Assistant Professor of Biological Sciences. In 2018 he was awarded one of five Outstanding Teacher Awards by the School of Natural Sciences and Mathematics. Dr. Campbell is the head of the RNA Control Lab and a member of the Center for Advanced Pain Studies and the Texas Pain Research Consortium. His research interests focus on RNA and how "regulatory information encoded by untranslated regions present in mRNA relates to pain amplifying behavior" with the goal of designing "mechanism-based inhibitors of RNA-protein interactions."

ORCID page.

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Recent Submissions

  • Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain 

    Megat, Salim; Ray, Pradipta R.; Moy, Jamie K.; Lou, Tzu-Fang; Barragan-Iglesias, Paulino; Li, Yan; Pradhan, Grishma; Wanghzou, Andi; Ahmad, Ayesha; Burton, Michael D.; North, Robert Y.; Dougherty, Patrick M.; Khoutorsky, Arkady; Sonenberg, Nahum; Webster, Nevin R.; Dussor, Gregory; Campbell, Zachary T.; Price, Theodore J. (Soc Neuroscience, 2019-01-16)
    Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including ...

  • Emerging Neurotechnology for Antinoceptive Mechanisms and Therapeutics Discovery 

    Black, Bryan J.; Atmaramani, Rahul; Plagens, Sarah; Campbell, Zachary T.; Dussor, Gregory; Price, Theodore J.; Pancrazio, Joseph J. (Elsevier Advanced Technology, 2018-11-13)
    The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to ...

  • Engineering a Conserved RNA Regulatory Protein Repurposes its Biological Function in Vivo 

    Bhat, Vandita D.; McCann, Kathleen L.; Wang, Yeming; Fonseca, Dallas R.; Shukla, Tarjani; Alexander, Jacqueline C.; Qiu, Chen; Wickens, Marv; Lo, Te-Wen; Hall, Traci M. Tanaka; Campbell, Zachary T. (eLife Sciences Publications Ltd, 2019-01-17)
    PUF (PUmilio/FBF) RNA-binding proteins recognize distinct elements. In C. elegans, PUF-8 binds to an 8-nt motif and restricts proliferation in the germline. Conversely, FBF-2 recognizes a 9-nt element and promotes mitosis. ...

  • Activation of the Integrated Stress Response in Nociceptors Drives Methylglyoxal-Induced Pain 

    Barragan-Iglesias, Paulino; Kuhn, Jasper; Vidal-Cantu, Guadalupe C.; Belen Salinas-Abarca, Ana; Granados-Soto, Vinicio; Dussor, Gregory; Campbell, Zachary T.; Price, Theodore J. (Lippincott Williams & Wilkins, 2019-01)
    Methylglyoxal (MGO) is a reactive glycolytic metabolite associated with painful diabetic neuropathy at plasma concentrations between 500 nM and 5 μM. The mechanisms through which MGO causes neuropathic pain at these ...

  • Global Pairwise RNA Interaction Landscapes Reveal Core Features of Protein Recognition 

    Zhou, Qin; Kunder, Nikesh; De La Paz, Jose Alberto; Lasley, Alexandra E.; Bhat, Vandita D.; Morcos, Faruck; Campbell, Zachary T.
    RNA-protein interactions permeate biology. Transcription, translation, and splicing all hinge on the recognition of structured RNA elements by RNA-binding proteins. Models of RNA-protein interactions are generally limited ...

  • Inhibition of Poly(A)-Binding Protein with a Synthetic RNA Mimic Reduces Pain Sensitization in Mice 

    Barragan-Iglesias, Paulino; Lou, Tzu-Fang; Bhat, Vandita D.; Megat, Salim; Burton, Michael D.; Price, Theodore J.; Campbell, Zachary T. (Nature Publishing Group, 2018-10-22)
    Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of ...