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dc.contributor.authorHuang, Yuefengen_US
dc.contributor.authorMohan, Anushaen_US
dc.contributor.authorDe Ridder, Dirken_US
dc.contributor.authorSunaert, Stefanen_US
dc.contributor.authorVanneste, Svenen_US
dc.date.accessioned2018-10-22T19:32:51Z
dc.date.available2018-10-22T19:32:51Z
dc.date.created2018-01-17
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/6217
dc.description.abstractAlcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in cortical regions including the dorsal anterior cingulate cortex (dACC), nucleus accumbens (NAcc), posterior cingulate cortex (PCC) and pregenual anterior cingulate cortex (pgACC), etc. In this study, we combine these two imaging techniques to investigate a group of alcohol-addicted patients and provide convergent evidence for the neural correlates of craving not only in alcohol but substance abuse in general. We observe abnormal BOLD signal levels in the dACC, NAcc, pgACC, PCC, amygdala, and parahippocampus (PHC) in a cue-reactivity fMRI experiment. These findings are consistent with increased beta-band activity in the dACC and pgACC in resting-state EEG. We further observe desynchronization characterized by decreased functional connectivity in cue-based fMRI and hypersynchronization characterized by increased functional connectivity between these regions in the theta frequency band. The results of our study show a consistent pattern of alcohol craving elicited by external cues and internal desires. Given the advantage of superior spatial and temporal resolution, we hypothesize a "central craving network" that integrates the different aspects of alcohol addiction into a unified percept.en_US
dc.language.isoenen_US
dc.relation.urihttp://dx.doi.org/10.1038/s41598-017-18471-yen_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2018 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAlcoholismen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectElectroencephalographyen_US
dc.subjectGyrus Cingulien_US
dc.subjectNucleus accumbensen_US
dc.subjectAmygdaloid bodyen_US
dc.subjectHippocampusen_US
dc.titleThe Neural Correlates of the Unified Percept of Alcohol-Related Craving: A fMRI and EEG Studyen_US
dc.typeTexten_US
dc.type.genrearticleen_US
dc.description.departmentSchool of Behavioral and Brain Sciencesen_US
dc.identifier.bibliographicCitationHuang, Yuefeng, Anusha Mohan, Dirk De Ridder, Stefan Sunaert, et al. 2018. "The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study." Scientific Reports 8(1), doi:10.1038/s41598-017-18471-yen_US
dc.source.journalScientific Reportsen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.contributor.utdAuthorHuang, Yuefengen_US
dc.contributor.utdAuthorMohan, Anushaen_US
dc.contributor.utdAuthorVanneste, Svenen_US


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