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dc.contributor.authorVanneste, Svenen_US
dc.contributor.authorMartin, Jeffrey S.en_US
dc.contributor.authorRennaker, Robert L.en_US
dc.contributor.authorKilgard, Michael P.en_US
dc.descriptionIncludes supplementary materialen_US
dc.description.abstractRecent research has shown that vagus nerve stimulation (VNS) paired with tones or with rehabilitative training can help patients to achieve reductions in tinnitus perception or to expedite motor rehabilitation after suffering an ischemic stroke. The rationale behind this treatment is that VNS paired with experience can drive neural plasticity in a controlled and therapeutic direction. Since previous studies observed that gamma activity in the auditory cortex is correlated with tinnitus loudness, we assessed resting-state source-localized EEG before and after one to three months of VNS-tone pairing in chronic tinnitus patients. VNS-tone pairing reduced gamma band activity in left auditory cortex. VNStone pairing also reduced the phase coherence between the auditory cortex and areas associated with tinnitus distress, including the cingulate cortex. These results support the hypothesis that VNS-tone pairing can direct therapeutic neural plasticity. Targeted plasticity therapy might also be adapted to treat other conditions characterized by hypersynchronous neural activity.en_US
dc.publisherNature Publishing Groupen_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2017 The Authorsen_US
dc.subjectAuditory cortexen_US
dc.subjectOutcomes research (Medical care)en_US
dc.subjectVagus nerveen_US
dc.titlePairing Sound with Vagus Nerve Stimulation Modulates Cortical Synchrony and Phase Coherence in Tinnitus: An Exploratory Retrospective Studyen_US
dc.description.departmentSchool of Behavioral and Brain Sciencesen_US
dc.identifier.bibliographicCitationVanneste, Sven, Jeffrey Martin, Robert L. Rennaker, and Michael P. Kilgard. 2017. "Pairing sound with vagus nerve stimulation modulates cortical synchrony and phase coherence in tinnitus: An exploratory retrospective study." Scientific Reports 7, doi:10.1038/s41598-017-17750-yen_US
dc.source.journalScientific Reportsen_US
dc.contributor.utdAuthorVanneste, Svenen_US
dc.contributor.utdAuthorMartin, Jeffrey S.en_US
dc.contributor.utdAuthorRennaker, Robert L.en_US
dc.contributor.utdAuthorKilgard, Michael P.en_US
dc.contributor.ISNI0000 0001 2879 2132 (Rennaker, RL)en_US
dc.contributor.ISNI0000 0001 3852 473X (Kilgard, MP)en_US
dc.contributor.ORCID0000-0002-9906-1836 (Vanneste, S)en_US

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CC BY 4.0 (Attribution)
Except where otherwise noted, this item's license is described as CC BY 4.0 (Attribution)