Search
Now showing items 1-10 of 11
Frontostriatal White Matter Connectivity: Age Differences and Associations with Cognition and BOLD Modulation
(Elsevier Inc., 2020-06-07)
Despite the importance of cortico-striatal circuits to cognition, investigation of age effects on the structural circuitry connecting these regions is limited. The current study examined age effects on frontostriatal white ...
Differential Aging Trajectories of Modulation of Activation to Cognitive Challenge in APOEε4 Groups: Reduced Modulation Predicts Poorer Cognitive Performance
The present study was designed to investigate the effect of a genetic risk factor for Alzheimer's disease (AD), ApolipoproteinE ε4 (APOEε4), on the ability of the brain to modulate activation in response to cognitive ...
Evaluation and Calibration of Short-Term Aging Effects in Speaker Verification
A speaker verification evaluation is presented on the Multisession Audio Research Project (MARP) corpus, for which speakers were recorded at regular intervals, in consistent conditions, over a period of three years. It is ...
To Switch or Not to Switch: Role of Cognitive Control in Working Memory Training in Older Adults
It is currently not known what are the best working memory training strategies to offset the age-related declines in fluid cognitive abilities. In this randomized clinical double-blind trial, older adults were randomly ...
Frontoparietal Cortical Thickness Mediates the Effect of COMT Val¹⁵⁸Met Polymorphism on Age-Associated Executive Function
(Elsevier Science Inc, 2018-09-21)
Proper dopamine (DA) signaling is likely necessary for maintaining optimal cognitive performance as we age, particularly in prefrontal-parietal networks and in fronto-striatal networks. Thus, reduced DA availability is a ...
Socioeconomic Status Moderates Age-Related Differences in the Brain's Functional Network Organization and Anatomy Across the Adult Lifespan
An individual's environmental surroundings interact with the development and maturation of their brain. An important aspect of an individual's environment is his or her socioeconomic status (SES), which estimates access ...
Shorter Term Aerobic Exercise Improves Brain, Cognition, and Cardiovascular Fitness in Aging
Physical exercise, particularly aerobic exercise, is documented as providing a low cost regimen to counter well-documented cognitive declines including memory, executive function, visuospatial skills, and processing speed ...
Higher-Order Cognitive Training Effects on Processing Speed-Related Neural Activity: A Randomized Trial
Higher-order cognitive training has shown to enhance performance in older adults, but the neural mechanisms underlying performance enhancement have yet to be fully disambiguated. This randomized trial examined changes in ...
Age-Related Similarities and Differences in Brain Activity Underlying Reversal Learning
(2013-05-29)
The ability to update associative memory is an important aspect of episodic memory and a critical skill for social adaptation. Previous research with younger adults suggests that emotional arousal alters brain mechanisms ...
Genetic Predisposition for Inflammation Exacerbates Effects of Striatal Iron Content on Cognitive Switching Ability in Healthy Aging
(Academic Press Inc Elsevier Science, 2018-10-25)
Non-heme iron homeostasis interacts with inflammation bidirectionally, and both contribute to age-related decline in brain structure and function via oxidative stress. Thus, individuals with genetic predisposition for ...