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dc.contributor.authorBin Yoo, Hye
dc.contributor.authorde la Concha, Edward Omar
dc.contributor.authorDe Ridder, D.
dc.contributor.authorPickut, B. A.
dc.contributor.authorVanneste, Sven
dc.description.abstractEarly and moderate Parkinson's disease patients seem to have attention dysfunctions manifested differentially in separate attention streams: Top-down and bottom-up. With a focus on the neurophysiological underpinnings of such differences, this study evaluated source-localized regional activity and functional connectivity of regions in the top-down and bottom-up streams as well as any discordance between the two streams. Resting state electroencephalography was used for 36 Parkinson's disease patients and 36 healthy controls matched for age and gender. Parkinson's disease patients showed disproportionally higher bilateral gamma activity in the bottom-up stream and higher left alpha2 connectivity in the top-down stream when compared to age-matched controls. An additional cross-frequency coupling analysis showed that Parkinson's patients have higher alpha2-gamma coupling in the right posterior parietal cortex, which is part of the top-down stream. Higher coupling in this region was also associated with lower severity of motor symptoms in Parkinson's disease. This study provides evidence that in Parkinson's disease, the activity in gamma frequency band and connectivity in alpha2 frequency band is discordant between top-down and bottom-up attention streams. © 2018 The Author(s).
dc.publisherNature Publishing Group
dc.rightsCC BY 4.0 (Attribution)
dc.rights©2018 The Authors
dc.subjectParietal Lobe
dc.subjectParkinson's disease
dc.titleThe Functional Alterations in Top-Down Attention Streams of Parkinson's Disease Measured by EEG
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.identifier.bibliographicCitationBin Yoo, H., E. O. de la Concha, D. De Ridder, B. A. Pickut, et al. 2018. "The Functional Alterations in Top-Down Attention Streams of Parkinson's Disease Measured by EEG." Scientific Reports 8: art. 10609, doi: 10.1038/s41598-018-29036-y
dc.source.journalScientific Reports
dc.contributor.utdAuthorBin Yoo, Hye
dc.contributor.utdAuthorde la Concha, Edward Omar
dc.contributor.utdAuthorVanneste, Sven
dc.contributor.ORCID0000-0002-9906-1836 (Vanneste, S)

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