Transport and Interactions of Nanoparticles in the Kidneys

Date

ORCID

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

item.page.doi

Abstract

Kidneys are a major organ for blood filtration and waste elimination and thus play a key role in the transport and clearance of nanoparticles in vivo. The interactions of nanoparticles with different kidney compartments can be precisely regulated by modulating their size, shape and surface chemistry. The quantitative understanding of nanoparticle–kidney interactions at the molecular level is important for improving disease targeting, precisely controlling nanoparticle transport and clearance, and minimizing the potential health hazards of nanomedicines. In this Review, we summarize the glomerular filtration of macromolecules and nanoparticles in the kidney and survey kidney imaging techniques for the study of nanoparticle–kidney interactions ex vivo and in vivo. We investigate the different transport mechanisms of nanoparticles in the kidneys and discuss size, charge and shape dependencies in renal clearance. Nanoparticles are then investigated for the preclinical and clinical detection and treatment of diseases such as kidney dysfunction and cancer. Finally, challenges and opportunities for renal-clearable nanoparticles are highlighted. © 2018, Springer Nature Limited.

Description

Full text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided Link to Article).

Keywords

Nanomedicine, Nanoparticles, Kidneys—Diseases, Surface chemistry, Blood—Filtration, Glomerular filtration rate, Review

item.page.sponsorship

National Institutes of Health (NIH R01DK103363 and R43DK116368), the Cancer Prevention and Research Institute of Texas (CPRIT RP140544 and RP160866), and the Welch Research Foundation (AT-1974-20180324).

Rights

©2018

Citation

Collections